June 2015
Volume 56, Issue 7
ARVO Annual Meeting Abstract  |   June 2015
Management and Outcomes of Uveitis in a Tertiary Eye Center Over 30 Years
Author Affiliations & Notes
  • Chang Sup Lee
    Ophthalmology, University of Virginia, Charlottesville, VA
  • Asima Bajwa
    Ophthalmology, University of Virginia, Charlottesville, VA
  • James Patrie
    Biostatistics, University of Virginia, Charlottesville, VA
  • Wenjun Xin
    Biostatistics, University of Virginia, Charlottesville, VA
  • Ashvini Reddy
    Ophthalmology, University of Virginia, Charlottesville, VA
  • Footnotes
    Commercial Relationships Chang Sup Lee, None; Asima Bajwa, None; James Patrie, None; Wenjun Xin, None; Ashvini Reddy, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 5760. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Chang Sup Lee, Asima Bajwa, James Patrie, Wenjun Xin, Ashvini Reddy; Management and Outcomes of Uveitis in a Tertiary Eye Center Over 30 Years. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5760.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

To report the long-term, clinical outcomes of patients with uveitis managed in a tertiary medical center at University of Virginia over a 30 year period.


Retrospective, observational study of patients with uveitis seen at the University of Virginia from 1984-2014. Descriptive statistics and, where appropriate, Wilcoxon Rank Sum test and Pearson's Exact Chi-Square test were used to analyze demographics, laterality, anatomic location, etiology, total number of visits, change in best-corrected visual acuity (BCVA), management, intraocular pressure (IOP), and cataract.


The study included 644 eyes of 491 patients. 153 patients (31.2%) had bilateral disease and 213 (43.4%) were male. Mean age was 51.7±1.1 (SE) years at presentation. The mean number of visits per patient was 11.2±14.8 (median 6.0; range, 1.0-155).<br /> <br /> The mean BCVA was 0.54±0.03 logMAR at initial presentation and 0.52±0.04 logMAR (P=0.002) at last follow-up. Change in mean visual acuity from presentation to last follow-up was not statistically significant for anterior (0.44±0.04 to 0.45±0.04, P=0.058), posterior (1.07±0.13 to 0.99±0.13, P=0.197) and panuveitis (0.43±0.05 to 0.45±0.08, P=0.216). For patients with intermediate uveitis, the mean BCVA significantly improved by the final visit (0.61±0.17 and 0.27±0.07, P=0.038). Severe vision loss (>1.0 logMAR) was rarely seen with traumatic uveitis and HLA-B27-associated anterior uveitis.<br /> <br /> Local steroids were given to 365 patients (74.6%) and systemic steroids to 133 (27.3%). Antimetabolites were used in 52 (10.6%) patients and anti-tumor necrosis factor agents in 17 (3.5%). Intravitreal injection was given to 54 patients (11.1%); subtenon injection was given to 23 (4.7%). Vitrectomy was performed in 46 patients (9.4%). Mean initial IOP was 15.8±6.4 mmHg, and mean final IOP was 14.9±5.0 mmHg. 116 (23.7%) patients received medical treatment for ocular hypertension (IOP>21 mmHg), and 43 (8.8%) patients underwent glaucoma surgery. 129 (26.4%) patients underwent cataract surgery.


In this large series of patients with uveitis, mean BCVA improved from initial presentation to last follow-up, and this improvement was statistically significant. Patients with intermediate uveitis had a better final visual acuity than those with anterior, posterior or panuveitis. The majority of patients were managed with local or systemic steroids, and many developed glaucoma and cataract requiring treatment.


This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.