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BEATRIZ VALADEZ BLANCO, Miguel Pedroza Seres; Pediatric uveitis in a reference Centre in Mexico.. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5761.
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© ARVO (1962-2015); The Authors (2016-present)
Uveitis (intraocular inflammation) is an important cause of blindness in México, 5% to 10% of the cases occurs in children. We performed this study to know about the relative occurrence of uveítis, the disease characteristics and its causes in pediatric population.
Observational and retrospective clinical study was performed, we analyzed the data of 8 years (January 2007 to August 2014) from 357 patients with uveitis in a reference centre in Mexico City and included 286 patients diagnosed from 0 to 18 years of age, with more than one visit and specific diagnosis. Data retrieved included age of diagnosis, gender, uveitis diagnosis, anatomic location, and laterality. Detailed clinical information regarding the course of uveitis included visual acuity, treatments, and if they were already treated. The Standardization of Uveitis Nomenclature criteria was used to report the clinical data.
Out of the 276 patients with uveitis 64.69% were male and 35.31% female with a male to female ratio of 1.8 to 1, median age at diagnosis was 10.4 years + 3.8 years, 61.54% had bilateral ocular involvement. Intermediate uveitis was the most common diagnosis 61.54%, followed by posterior uveitis 22.38%, anterior uveitis 14.69% and panuveitis 1.40%. The underlying cause for uveitis was evaluated as non-infectious 70.63%, infectious 21.27% and idiopathic 2.10%. The most common etiology was pars planitis for intermediate, parasite infestation for infectious association and the systemic disease association was juvenile idiopathic arthritis diagnosed in 1.39% of these children, The prevalence of legal blindness was 24.1% at baseline and at the end of treatment 20.27%. We treated 40.91% with corticosteroids (topical, periocular, intraocular, oral or intravenous), 38.81% received immunosuppressive drugs.
The results from this cohort show the spectrum of disease in pediatric patients. There are no many studies about uveitis in mexican population, far less in children, with this study we can determine the clinical characteristics of uveitis in this population that when compared with other studies there are different outcomes, like variations in the types of uveitis; we found a high rate of pars planitis.
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