Purchase this article with an account.
Russell W Read, Kinley Beck; Characteristics of Non-Infectious Persistent Postoperative Inflammation. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5799.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To determine the characteristics of patients diagnosed with non-infectious persistent postoperative inflammation and to determine if this diagnosis occurs more often in various subgroups (race and gender.)
Retrospective chart review of all patients seen between 2007 and 2010 (inclusive) at a single tertiary care academic uveitis center. Patients with non-infectious persistent postoperative inflammation were identified and compared to patients with other categories of uveitis. Characteristics were compared between groups using t-test and chi-square test for continuous and categorical variables, respectively.
732 patients were identified, 28 of which were diagnosed with non-infectious persistent postoperative inflammation (PPI)(3.8% of all patients). All but 3 cases followed cataract surgery and lens implantation. Of the 3 non-cataract cases, 2 were following trabeculectomy and one following SLT. All 28 had anterior disease, so comparison to non-PPI patients was limited to those with anterior uveitis (n = 485). The mean age at disease onset for PPI was 62 years (range 10-74) versus 45 years (range 1-94) for non-PPI patients (p=0.00001). Of patients with PPI, 29% were male, 71% female as compared to 33% male and 67% female for non-PPI patients (p = 0.64). Of PPI patients, African Americans comprised 61%, Caucasians 36%, and "Other" 4% versus for non-PPI, African Americans comprised 41%, Caucasians 57%, and "Other" 2% (p = 0.079). PPI patients manifested bilateral disease in 25% of cases, unilateral in 75% versus in non-PPI disease bilateral cases were 37% and unilateral 63% (p = 0.19). Of PPI patients with bilateral disease, 86% were African American and 14% were Caucasian. Of PPI patients with unilateral disease, 55% were African American and 45% were Causcian. Stated conversely, of African American PPI patients, 35% had bilateral disease, 65% unilateral disease. Of Caucasian PPI patients, 10% had bilateral disease, 90% unilateral disease (p = 0.15).
Persistent postoperative inflammation occurs most commonly following cataract surgery and is anterior. Females are more likely to be affected but not to a greater degree than in non-PPI anterior uveitis. A trend towards a higher frequency in African Americans was found and African Americans were more likely to have bilateral PPI, though not to a statistically significant degree.
This PDF is available to Subscribers Only