June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Heritability of anterior segment optical coherence tomography parameters in the Indian Family Angle Closure Evaluation
Author Affiliations & Notes
  • Robert Wojciechowski
    Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD
    Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD
  • Pradeep Y Ramulu
    Ophthalmology, Johns Hopkins School of Medicine, Baltimore, MD
  • Sabyasachi Sengupta
    Aravind Eye Hospital, Pondicherry, India
  • Palaniswamy Krishnamurthy
    Aravind Eye Hospital, Pondicherry, India
  • Srinivasan Kavitha
    Aravind Eye Hospital, Pondicherry, India
  • Periasamy Sundaresan
    Genetics, Aravind Eye Hospital, Madurai, India
  • Rengaraj Venkatesh
    Aravind Eye Hospital, Pondicherry, India
  • Footnotes
    Commercial Relationships Robert Wojciechowski, None; Pradeep Ramulu, None; Sabyasachi Sengupta, None; Palaniswamy Krishnamurthy, None; Srinivasan Kavitha, None; Periasamy Sundaresan, None; Rengaraj Venkatesh, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 5818. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Robert Wojciechowski, Pradeep Y Ramulu, Sabyasachi Sengupta, Palaniswamy Krishnamurthy, Srinivasan Kavitha, Periasamy Sundaresan, Rengaraj Venkatesh; Heritability of anterior segment optical coherence tomography parameters in the Indian Family Angle Closure Evaluation. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5818. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: We previously reported a very high sibling recurrence risk of angle-closure (AC) in a South Indian population. In the current study, we report on the heritability (h2) of quantitative parameters measured using anterior segment optical coherence tomography (ASOCT) in 631 individuals in 305 sibships in the Indian Family Angle Closure Evaluation.

Methods: AC (i.e., either AC suspects, primary angle closure or primary angle closure glaucoma) and open-angle control (OA) probands and their siblings were examined at the Aravind Eye Hospital glaucoma specialty clinic in Pondicherry, India. All participants received a complete eye examination and full glaucoma workup. ASOCT (Zeiss Visante) was performed on both eyes under ambient light and dark illumination. AC biometric parameters were estimated using automated image analysis software. These included AC width (ACW); AC depth (ACD); AC area; angle-opening distances (AOD); angle recess area (ARA), trabecular-iris spacing (TISA); iris area (IA); iris thickness (IT); maximum iris thickness, iris volume; and iris concavity. Means or first principal components (PC1) of parameters measured at multiple locations and illuminations (e.g., AOD, TISA, etc.) were used as derived traits in the analyses. H2 estimates were obtained for each derived trait using generalized estimating equations and computing the residual within-sibship correlation matrix after adjusting for age and sex.

Results: PC1 explained 47% (IA) to 73% (TISA, AOD) of the variance of AC parameters. H2 of AC parameters ranged from 48% (ACD) to >80% (AOD, ARA, TISA, IT). ACD had a lower (pseudo)h2 in AC sibships (2%; NS) compared to OA sibships (40%). Iridolenticular contact (IC) parameters had relatively low h2 (14-30%) although PC1 for IC explained less than 35% of their variances.

Conclusions: Our results show that AS biometric parameters measured with ASOCT are highly heritable in a South Indian population. Interestingly, ACD—a measure often used as a clinical predictor of AC glaucoma development—was uncorrelated in AC siblings. Though numerous measures were taken at different anatomical locations and illumination conditions, one principal component was generally sufficient to capture >50% of the variability of these parameters, simplifying their clinical interpretation and utility.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×