June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
High Resolution Imaging of Hard Exudates Using AO-SLO
Author Affiliations & Notes
  • Muneo Yamaguchi
    Ophthalmology, Kyushu University, Fukuoka-shi, Japan
  • Shintaro Nakao
    Ophthalmology, Kyushu University, Fukuoka-shi, Japan
  • Yoshihiro Kaizu
    Ophthalmology, Kyushu University, Fukuoka-shi, Japan
  • Yoshiyuki Kobayashi
    Ophthalmology, Kyushu University, Fukuoka-shi, Japan
  • Takahito Nakama
    Ophthalmology, Kyushu University, Fukuoka-shi, Japan
  • Shigeo Yoshida
    Ophthalmology, Kyushu University, Fukuoka-shi, Japan
  • Yuji Oshima
    Ophthalmology, Kyushu University, Fukuoka-shi, Japan
  • Tatsuro Ishibashi
    Ophthalmology, Kyushu University, Fukuoka-shi, Japan
  • Footnotes
    Commercial Relationships Muneo Yamaguchi, None; Shintaro Nakao, None; Yoshihiro Kaizu, None; Yoshiyuki Kobayashi, None; Takahito Nakama, None; Shigeo Yoshida, None; Yuji Oshima, None; Tatsuro Ishibashi, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 588. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Muneo Yamaguchi, Shintaro Nakao, Yoshihiro Kaizu, Yoshiyuki Kobayashi, Takahito Nakama, Shigeo Yoshida, Yuji Oshima, Tatsuro Ishibashi; High Resolution Imaging of Hard Exudates Using AO-SLO. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):588. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: Hard exudates are observed in fundus of retinal vascular diseases including diabetic retinopathy. Previous histological studies in autopsy specimen have shown these characteristics. However, the detailed characteristics of hard exudates has not been investigated in vivo patients with retinal vascular diseases.

Methods: Twenty-one eyes of nineteen patients with hard exudates were examined. We imaged hard exudates using spectral domain OCT (SD-OCT) and prototype adaptive optics scanning light ophthalmoscopy (AO-SLO) systems in all patients. The characteristics (location, size, morphology, and reflection patter) were investigated.

Results: AO-SLO showed two morphological types of hard exudates which could not be distinguished from the fundus examination. One type is accumulated round particles (28.9±5.4µm) (round type; major axis: 374±236μm, area: 63091±9970μm2, reflective intensity: 134±24). Another type is an irregular shaped hyperreflective deposition (irregular type; major axis: 227±133μm, area: 24659±8076μm2, reflective intensity:132±19). The area as well as the major axis in round type were significantly bigger than of irregular type, whereas there was no significant difference of the reflective intensity and the vertical location. Both types could be observed in all diseases. These types could change into each other.

Conclusions: High resolution imaging revealed two types of hard exudates. One could consist of phagocytes (round type) and another could be lipid or proteinaceous materials (irregular type). In vivo observation of hard exudates using AO-SLO confirmed to the previous histopathological findings.

×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×