June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Depth-resolved imaging of the parafoveal capillary network in diabetic retinopathy using swept source OCT-microangiography
Author Affiliations & Notes
  • Laura Kuehlewein
    Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA
    Department of Ophthalmology, David Geffen School of Medicine, University of California - Los Angeles, Los Angeles, CA
  • Tudor Tepelus
    Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA
    Department of Ophthalmology, David Geffen School of Medicine, University of California - Los Angeles, Los Angeles, CA
  • Lin An
    Carl Zeiss Meditec, Inc., Dublin, CA
  • Mary K Durbin
    Carl Zeiss Meditec, Inc., Dublin, CA
  • Srinivas R Sadda
    Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, CA
    Department of Ophthalmology, David Geffen School of Medicine, University of California - Los Angeles, Los Angeles, CA
  • Footnotes
    Commercial Relationships Laura Kuehlewein, None; Tudor Tepelus, None; Lin An, Carl Zeiss Meditec, Inc., Dublin, CA (E); Mary Durbin, Carl Zeiss Meditec, Inc., Dublin, CA (E); Srinivas Sadda, Carl Zeiss Meditec (C), Carl Zeiss Meditec (F), Carl Zeiss Meditec (R), Optos (C), Optos (F), Optos (R)
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 5918. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Laura Kuehlewein, Tudor Tepelus, Lin An, Mary K Durbin, Srinivas R Sadda; Depth-resolved imaging of the parafoveal capillary network in diabetic retinopathy using swept source OCT-microangiography. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5918.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose
 

To characterize the foveal avascular zone (FAZ) and the parafoveal capillary network at different retinal layers using swept source OCT-microangiography (OMAG) in normal subjects and patients with diabetic retinopathy.

 
Methods
 

OMAG images were acquired in 15 eyes of 11 patients with diabetic retinopathy, and 19 eyes of 13 healthy individuals using a prototype swept source OCT (Carl Zeiss Meditec), with a central wavelength of 1050nm. Scans were taken in clusters of 4 repeated B-scans from 3x3x3mm cubes centered on the fovea. En-face images of the retinal vasculature were generated from the superficial and deeper inner retinal layer (SRL/DRL) using a proprietary intensity differentiation algorithm. The area of the FAZ was computed at each en-face level following manual segmentation of the FAZ border. In addition, the parafoveal vessel density in a ring with a distance of 500 microns from the border of the foveal avascular zone was computed following automatic extraction using the publically available GNU Image Manipulation Program GIMP 2.8.14 (http://gimp.org). Vessel density was expressed as percent retinal area occupied by vessels.

 
Results
 

The values for mean ± SD area of the FAZ are shown in Table 1. The mean size of the FAZ was statistically significantly larger in patients with diabetic retinopathy for both the SRL and DRL (p<0.001 and p=0.002). The mean ± SD vessel density in the parafoveal ring is shown in Table 1. The mean parafoveal vessel density at the SRL was statistically significantly smaller in patients with diabetic retinopathy (p<0.001). At the DRL, however, there was no statistically significant difference in the vessel density when comparing patients with diabetic retinopathy and healthy individuals (p=0.552).

 
Conclusions
 

The foveal avascular zone was significantly larger in patients with diabetic retinopathy. The parafoveal vessel density was significantly smaller in patients with diabetic retinopathy at the superficial inner retinal layer. At the deeper inner retinal layer, however, the vessel density in patients with diabetic retinopathy was comparable to those in healthy subjects.  

 
Table 1. Mean and standard deviation (SD) of the area of the foveal avascular zone (FAZ) and parafoveal vessel density in patients with diabetic retinopathy and healthy individuals at the superficial and deeper inner retinal layer (SRL/DRL).
 
Table 1. Mean and standard deviation (SD) of the area of the foveal avascular zone (FAZ) and parafoveal vessel density in patients with diabetic retinopathy and healthy individuals at the superficial and deeper inner retinal layer (SRL/DRL).

 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×