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Xingwei Wang, Ben K Jang, Qienyuan Zhou; Analysis of the Bruch’s Membrane/RPE Complex in Normal and Dry AMD Subjects with Avanti SD-OCT. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):5962.
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To analyze the retinal pigment epithelium (RPE) elevation and choroid illumination pattern in normal and dry AMD subjects using Avanti SD-OCT (Optovue, Fremont, CA).
20 normal subjects (age 26 to 60, 15 male and 5 female) and 19 dry age related macular degeneration - AMD patients (age 66 to 90, 7 male and 12 female) were enrolled following an IRB approved study protocol. The 19 dry AMD patients consist of 10 early AMD patients and 9 GA patients. One eye per subject were included in the study. Each subject had three repeated 3D OCT scans of 8mm x 8mm in scan filed with integrated motion correction technology (MCT). 117 scans were acquired excluding 6 scans (5.1%) due to poor signal or poor fixation, a total of 111 scans were included in the analysis.
Areas of RPE elevation and increased choroid illumination were measured in the grid sectors of Early Treatment Diabetic Retinopathy Study (ETDRS) (Figure 1). For normal subjects, 93.3% (56/60) and 95% (57/60) of the total 60 scans have no detection of the RPE elevation and the increased choroid illumination, respectively. The (min, mean, max) of the detection areas (mm2) in the total ETDRS region for RPE elevation and increased choroid illumination are (0.000, 0.016, 0.090) and (0.000, 0.056, 0.880), respectively. For early AMD subjects, the (min, mean, max) of the RPE elevation areas are (0.550, 1.133, 2.293) with the repeatability of 0.069 mm2. For GA subjects, the (min, mean, max) of increased choroid illumination areas are (0.460, 6.180, 13.477) with the repeatability of 0.350 mm2.
The analysis shows promising detection results for both normal and AMD subjects in Avanti SD-OCT system.
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