June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
Interocular Symmetry in Spatial Distribution of Diabetic Retinal Lesions
Author Affiliations & Notes
  • Sung Yong Park
    Ophthalmology, Soonchunhyang Univ. Cheonan Hospital, Cheonan-si, Korea (the Republic of)
  • Da Ye Choi
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (the Democratic People's Republic of)
  • Mingui Kong
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (the Democratic People's Republic of)
  • Don-Il Ham
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea (the Democratic People's Republic of)
  • Footnotes
    Commercial Relationships Sung Yong Park, None; Da Ye Choi, None; Mingui Kong, None; Don-Il Ham, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 601. doi:
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      Sung Yong Park, Da Ye Choi, Mingui Kong, Don-Il Ham; Interocular Symmetry in Spatial Distribution of Diabetic Retinal Lesions. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):601.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To assess the interocular symmetry in spatial distribution of diabetic retinal lesions using ultra-wide-field imaging.

Methods: Imaging data of patients who had diabetic retinopathy and underwent ultra-wide-field angiography (UWFA) were retrospectively investigated. Fundus in each UWFA image was divided into 2 or 4 subfields by a grid with horizontal and vertical straight lines centered at the fovea. Fundus was also divided into central and peripheral subfields by a rectangle grid. UWFA images taken just after completion of arteriovenous phase were evaluated for microaneurysm (Ma), presumed intraretinal microvascualr abnormalities (IRMA), and non-perfusion area (NPA) on each subfield. Each subfield was scored in a scale of 0-4 for each retinal lesion, based on the detected number of corresponding lesion. Interocular agreements of score in each subfield and interocular agreements of score difference between different subfields were analyzed using a Kappa index.

Results: Two hundred eighty eight eyes of 144 patients were evaluated; 244 eyes (84.7%) had non-proliferative diabetic retinopathy (NPDR), and 42 eyes (14.6%) had proliferative diabetic retinopathy. Significant interocular agreement was found in the score of Ma (Superior/Inferior: 0.67/0.74, Nasal/Temporal: 0.87/0.89 , Central/Peripheral: 0.89/0.80), presumed IRMA (Superior/Inferior: 0.82/0.87, Nasal/Temporal:0.91/0.76, Central/Peripheral: 0.93.0.89), and NPA(Superior/Inferior: 0.86.0.65 , Nasal/Temporal: 0.87/0.81, Central/Peripheral: 0.97/0.94). High interocular agreement was also found for the score difference between two vertical half subfields, two horizontal half subfields, and central versus peripheral subfields ( P<0.05). A kappa index for intragrader and intergrader agreement was between 0.60 and 0.93.

Conclusions: There was significant interocular symmetry in the spatial distribution of diabetic retinal lesions. This finding can be useful for the screening examination and longitudinal evaluation of diabetic retinopathy.

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