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Dragana Drobnjak, Nina Veiby, Torben Jørgensen, Line Kessel, Michael Larsen; Lens fluorescence and retinal vessel diameter in the Inter99 Eye Study. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):608.
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We know from previous studies that the risk of ischemic heart disease is strongly related to lens fluorophore accumulation and that the relationship is attributable to tobacco smoking and dysglycemia. Retinal vessel diameter changes are also associated with smoking, dysglycemia and ischemic heart disease. The purpose of this study was to examine the relationship between lens fluorescence and retinal vessel diameter
The Inter99 study comprised an age- and sex-stratified sample of 13,016 participants residing in 11 suburban municipalities of the south-western part of Copenhagen County. Of 6784 subjects aged 30-60 years who volunteered to participate in the main study, a subgroup of 970 subjects participated in the eye study. Retinal blood vessels were measured using a semi-automatic computer program. All study subjects not having good and clear images (n=62) were excluded. The analysis comprised a group of 908 subjects. We investigated the relation between fundus photographic retinal vessel diameters and lens fluorescence with adjustment for age, sex, and arterial blood pressure. Vessel diameters were expressed as central retinal artery equivalent diameter (CRAE) and central retinal vein equivalent diameter (CRVE). Lens aging was quantified by lens fluorometry. The degree of cortical lens opacities was graded according to the LOCS III scale
CRAE increased with increasing lens fluorescence by 0.008 µm/ng f-eq/ml (CI95%: -0.001 to 0.016, p=0.081) after adjusting for age, sex, and systolic blood pressure. CRVE increased with increasing lens fluorescence by 0.013 µm/ng f-eq/ml (CI95%: 0.001 to 0.025, p=0.037) after adjusting for age, sex, and systolic blood pressure<br />
In the Inter99 Eye study, wider vein diameters were significantly associated with lens fluorescence. The relationship may be attributable to the metabolic products affecting both the aging process of the lens and the retinal vessel diameters
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