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Magdalena Bajgrowicz, Chau-Minh Phan, Lakshman N Subbaraman, Lyndon William Jones; Release of ciprofloxacin and moxifloxacin from daily disposable contact lenses using an in vitro eye model. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):6085.
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© ARVO (1962-2015); The Authors (2016-present)
To analyze the release of two fluoroquinolones, ciprofloxacin and moxifloxacin, from conventional hydrogel (CH) and silicone hydrogel (SH) daily disposable commercial contact lenses (CLs) from a vial and an in vitro eye model.
Four CH CLs (nelfilcon A, omafilcon A, etafilcon A, ocufilcon B) and three SH CLs (somofilcon A, narafilcon A, delefilcon A) were incubated in a solution containing either ciprofloxacin or moxifloxacin for 24 h. After the incubation period, the lenses were placed in two release conditions: (1) a vial containing 4.8 mL of PBS for 24 hours and (2) an in vitro eye model with a PBS flow rate at 4.8 mL over 24 h. The amount of drugs released was determined using spectrophotometric technique.
The release in the vial for both drugs was very rapid, and reached a plateau between 15 min and 2 h for all lens types. In contrast, under under physiological flow conditions, a constant and slow release was observed over 24 h. The amounts of ciprofloxacin released from the lenses ranged between 49.6±0.7 to 62.8±0.3 µg/lens in the vial, and between 35.0±7.0 to 109.0±5.0 µg/lens in the eye model. Moxifloxacin release ranged from 24.0±4.0 to 226.0±2.0 µg/lens for the vial, and between 13.0±2.0 to 151.0±10.0 µg/lens in the eye model. In both systems and for both drugs, HEMA-based CLs released significantly more drug than other materials.
The parameters of the release system, in particular the volume of the release medium and flow rate, have a huge influence on release profiles. Under physiological flow conditions, release profiles were significantly slower and constant when compared with release in a vial model. The release is also affected by the material composition of the lens, and the water solubility of the drug.
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