Corneal displacement and biomechanical parameters in glaucoma subjects with different lens conditions

Abstract

Purpose: To evaluate the corneal displacements of eyes with glaucoma with different conditions of lens and factors associated with the corneal displacement.

Methods: Seventy two eyes with glaucoma from 46 subjects were included in this study. The subjects aged 38-87 years old. The IOP was measured and the corneal displacement was recorded using Corvis-ST. The biomechanical parameters obtained using Corvis-ST were compared. The central vertical corneal displacements were analyzed using MATLAB R2014a. The parameters were compared using Mann Whitney-U test. The multiple linear regression analysis with the stepwise method was used to examine the factors affecting corneal displacement and IOP.

Results: There were significant differences of the applanation 2 velocity and the highest concavity time between those with phakic glaucoma eyes and eyes with IOL. There were no significant differences of the central vertical corneal displacements at the IOP reading time, applanation time 2, and maximum displacements. The applanation 2 velocity, highest concavity time, and peak horizontal distance were significantly different between subjects with primary open-angle glaucoma (POAG) and subjects with primary angle-closure glaucoma (PACG). Age affected the corneal displacements at the IOP reading time.

Conclusions: Our results indicate that glaucoma and lens conditions changed the biomechanical parameters. Age affects the amount of corneal displacement and IOP.