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Yujeong Kim, DongHyun Kim, Kyung Chul Yoon, Mee Kum Kim, Won Ryang Wee; The Epidemiology of Dry Eye Disease in South Korea: Old age may be not a Major Risk factor in Dry Eye Disease.. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):6192.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the relation of old age and the other risk factors with dry eye disease (DED) in South Korea.
Design: Population based cross-sectional study<br /> We included 18,349 subjects between the ages of 19 and 97 year, from the 5th Korea National Health and Nutrition Examination Survey (KNHANES V) between 2010 and 2012<br /> DED was defined as previously diagnosed by an ophthalmologist or the presence of symptoms. Sociodemographic, medical, lifestyle, and ocular factors were assessed as potential risk factors for DED using univariate and multivariate logistic regression analysis.<br /> To assess the effect of age on DED, age-adjusted univariate odds ratio (OR) was compared with unadjusted OR regarding each variable and correlation analysis between DED prevalence and age was performed. DED in postmenopausal women according to hormone replacement therapy (HRT) were also investigated to evaluate the effect of sex hormone on DED.
Significant risk factors of DED were female sex (DED symptom/diagnosis OR=2.00/2.35, all p<0.0001), dyslipidemia [1.27/1.40], rheumatoid arthritis [1.24/1.47], depression [1.30/1.21], chronic renal failure [1.87/2.95], thyroid disease [1.47/1.65], sleeping < 7 hours [1.22/1.28], high perceived stress [1.27/1.18], poor subjective health awareness (good subjective health awareness OR=0.60/0.68, all p<0.0001), and previous ocular surgery [1.91/2.07, all p<0.0001] in multivariate logistic regression (all p<0.05). The OR of the elderly group (age≥65 year) for DED symptoms and diagnosis were 1.15/1.07[symtoms/diagnosis] (unadjusted univariate logictic regression, p>0.05)0.78/0.64(multivariate logistic regression, p<0.05), compared with the young group (age 19-40). In addition, the prevalence of DED symptoms and diagnosis did not increase with age (Pearson correlation, R2=0.0023, p 0.6937/R2=0.0011, p=0.7855). Postmenopausal women who had received HRT were more likely to have DED diagnosis than patients with no HRT history (multivariate OR=1.68, p=0.0001)
Age may not be a risk factor in DED in Korean population, while DED may be significantly associated by female sex, previous ocular surgery and poor subjective health awareness.
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