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Monica Mosca, Alessandro Rossi, Roberto Sala, Roberto Ratiglia; Comparison among Standard Automated Perimetry, Microperimetry and macular Spectral Domain-OCT in glaucomatous eyes with localized visual field defects. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):633.
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© ARVO (1962-2015); The Authors (2016-present)
To compare visual function evaluated by standard automatic perimetry (SAP) and microperimetry with ganglion cell inner plexiform layer (GCIPL) thickness in POAG eyes with visual field (VF) localized defects.
Cross-sectional study on 23 POAG patients (23 eyes) with VF localized defects (11 males, 12 females, mean age 69.1±9.2 years) and 23 normal subjects (23 eyes) (9 males, 14 females, mean age 66.2±9.5 years). Complete examination, SAP (Humphrey, prog.10-2 SITA standard), Nidek MP1 microperimetry (prog. Humphrey 10-2 pattern, 4-2 strategy, Goldmann III size stimulus projected on white background), Cirrus SD-OCT imaging of macula were performed. GCIPL thickness values in the retinal areas associated with hemifield localized perimetric defects were compared with corresponding undamaged areas. Student t-test and Pearson’s correlation coefficient (r) between the considered parameters and MD-PSD were used for statistical analysis.
Macular sensitivity was significantly inferior in POAGs than controls with both SAP and MP1 (p<0.001). A significant difference (p<0,001) in GCIPL thickness between POAG and control group was found (58.4±8.8μm vs 78.04±7.7μm respectively). In POAGs, GCIPL mean values, SAP 10-2 and MP1 mean sensitivity from the retinal areas associated with localized VF defects were significantly less (p<0.001) than in the corresponding VF undamaged areas (GCIPL 53.9±11.1μm vs 61.6±10.19μm; SAP 10-2 mean sensitivity 19.7±8.4dB vs 28.4±3.4dB; MP1 mean sensitivity 8.2±5.5dB vs 13.9±3.9dB). Mean values of the same parameters in the VF undamaged retinal areas of POAGs and in the corresponding sectors of controls were significantly (p<0.001) different (GCIPL 61.6±10.19μm vs 78.7±6.4μm; SAP 10-2 mean sensitivity 28.4±3.4dB vs 32.2±1.5dB; MP1 mean sensitivity 13.9±3.9dB vs 18.7±1.05dB). In POAGs, MD had a stronger correlation with mean total GCIPL thickness (r=0.508 p=0.013) than PSD (r=-0.185 p=0.39). SAP 10-2 and MP1 mean total sensitivity showed a good correlation with mean total GCIPL thickness (r=0.53, p=0.008 and r=0.49, p=0.016 respectively).
MP1 and SAP findings showed a very good correlation with a corresponding OCT macular thinning, suggesting they could provide a better understanding of the amount of glaucomatous damage in the macular region.
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