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Taiga Miyajima, Mayumi Nagata, Hiroyuki Matsushima, Koichiro Mukai, Masamoto Aose, Tadashi Senoo; Comparison of anterior capsule contraction between two different types of acrylic intraocular lenses. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):651.
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© ARVO (1962-2015); The Authors (2016-present)
The anterior capsule contraction is one of a complication after a cataract surgery which decreases visual functions according as their progression. In this study, we evaluate the ratios of anterior capsule contraction between two types of hydrophobic acryl intraocular lenses (IOLs).
The subject were 15 cases, 20eyes who were performed phacoemulcifiction (average age 70.7±8.1) and IOLs (ZCB00V: AMO or PY-60AD: HOYA) were randomly implanted. Images were taken using an EAS-1000 (NIDEK) after 1 week and 3 months postoperatively and ratio of anterior capsule contractions were calculated. At the same time, area of fibrosis on surface of IOLs were also calculated using area analyzing soft were (Area Q). Welch's t-test was performed for statistically analysis. To investigate the reasons of differences, we prepared white rabbit and performed cataract surgeries. Their tissue sections were obtained after 90 days and historical analysis were performed.<br />
The anterior capsule contractions of ZCB00V and PY-60AD were 0.88±1.25 % and 3.16±2.13 % respectively after 3 months. And there were statistically significance (P=0.04). The fibrosis area of ZCB00V and PY-60AD were 6.10±3.69 pixels and 37.65±10.21 pixels respectively. And there were statistically significance (P=0.0003). Histological studies show the hollow around the ZCB00V and it prevent the adhesion between anterior capsule and surface of IOL. The development of lens epithelial cells were prevented on ZCB00V.<br />
The ZCB00V has a hollow around the IOL and prevent adhesion between anterior capsule and surface of IOL, which inhibits fibroblastic changes and finally prevents anterior capsule contraction.
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