June 2015
Volume 56, Issue 7
ARVO Annual Meeting Abstract  |   June 2015
The use of matrix therapy in the treatment of corneal perforation.
Author Affiliations & Notes
  • Didier Renault
    Clinical Trials, Laboratoires Thea, Clermont-Ferrand, France
  • Sihem Lazreg
    Centre d'ophtalmologie lazreg, Blida, Algeria
  • Maya Benali abdellah
    Centre d'ophtalmologie lazreg, Blida, Algeria
  • Footnotes
    Commercial Relationships Didier Renault, LABORATOIRES THEA (E); Sihem Lazreg, None; Maya Benali abdellah, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 720. doi:
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      Didier Renault, Sihem Lazreg, Maya Benali abdellah; The use of matrix therapy in the treatment of corneal perforation.. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):720.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: Corneal perforation may be the most severe complication of ocular surface and corneal inflammation.

Methods: Patients with corneal perforation in Sjögren's syndrome disease were treated by Cacicol at the dose regimen of one drop every other day for 3 weeks associated to an hydrophilic contact lens. The follow up visits were performed every day the first week, then every week the first month.

Results: 5 cases of corneal perforation were treated, 4 females, mean age 73+/- 23 years, the size of the perforation was less than 1 mm in all cases, and the time between the perforation and the onset of the treatment was less than 24 hours. All the patients were treated for severe dry eye in Sjögren's disease for many years, the perforations were not painful in all cases. <br /> The beginning of corneal healing was observed between D3 and D7, and the total cicatrization of the perforation was observed at D15 for all patients.

Conclusions: Matrix therapy can be helpful in small size corneal perforation associated to contact lens bandage in absence of both amniotic membrane and biological glue.<br /> <br />


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