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Akiko Miki, Shigeru Honda, Yoshiko Matsumoto, Azusa Akashi, Yuko Yamada, Makoto Nakamura; The OCT findings of macula and associated factors in patients with a history of retinopathy of prematurity. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):950.
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© ARVO (1962-2015); The Authors (2016-present)
Retinopathy of prematurity (ROP) may cause various complications including high myopia, exotropia and amblyopia. In this study, we evaluated the OCT findings of macula in patients with a history of ROP and performed statistic analyses to clarify the factors associated with the OCT parameters.
Fifty-one eyes of 30 cases with ROP, and 99 eyes of 69 controls were included in this study. The mean age at the examination was 10±3.0 in the control group and 12±4.7 in the ROP group (p>0.05). We analyzed ocular length, refractive error, corneal curvature radius, best-corrected visual acuity (BCVA; logMAR). We also measured retinal thickness (fovea, temporal, nasal, superior, inferior), and the thickness of ganglion cell layer (GCL) and inner plexiform layer (IPL) (GCL+IPL) using OCT.
The ROP group showed lower refractive error, smaller corneal curvature radius, worse BCVA, thicker retinal thickness at the fovea, and the thinner GCL+IPL thickness than control group (p<0.01 each). In multivariate logistic regression analysis, refractive error had a significant correlation with corneal curvature radius (p<0.05), and foveal thickness was significantly correlated with GCL+IPL thickness (p<0.05).
Patients with a history of ROP had a lower refractive error likely due to the morphology of anterior segment. The foveal thickness in the eyes of the patients with a history of ROP was thicker than control, which was significantly associated with the thickness of GCL+IPL around the fovea.
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