June 2015
Volume 56, Issue 7
Free
ARVO Annual Meeting Abstract  |   June 2015
The relationship between ROP risk factors and central visual function in former premature children aged 6 to 12 years: interim results from the GRANIT study
Author Affiliations & Notes
  • Birgit Lorenz
    Department of Ophthalmology, Justus-Liebig University, Giessen, Germany
  • Wadim Bowl
    Department of Ophthalmology, Justus-Liebig University, Giessen, Germany
  • Kerstin Holve
    Department of Ophthalmology, Justus-Liebig University, Giessen, Germany
  • Silke Schweinfurth
    Department of Ophthalmology, Justus-Liebig University, Giessen, Germany
  • Christoph Friedburg
    Department of Ophthalmology, Justus-Liebig University, Giessen, Germany
  • Knut Stieger
    Department of Ophthalmology, Justus-Liebig University, Giessen, Germany
  • Monika Andrassi-Darida
    Department of Ophthalmology, Justus-Liebig University, Giessen, Germany
  • Footnotes
    Commercial Relationships Birgit Lorenz, None; Wadim Bowl, None; Kerstin Holve, None; Silke Schweinfurth, None; Christoph Friedburg, None; Knut Stieger, None; Monika Andrassi-Darida, None
  • Footnotes
    Support None
Investigative Ophthalmology & Visual Science June 2015, Vol.56, 952. doi:
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      Birgit Lorenz, Wadim Bowl, Kerstin Holve, Silke Schweinfurth, Christoph Friedburg, Knut Stieger, Monika Andrassi-Darida; The relationship between ROP risk factors and central visual function in former premature children aged 6 to 12 years: interim results from the GRANIT study. Invest. Ophthalmol. Vis. Sci. 2015;56(7 ):952.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: To correlate visual acuity (VA) and light increment sensitivity (LIS) with birth weight (BW) and gestational age (GA) in school aged former premature children, and to study the prevalence of strabismus, amblyopia and refractive errors in the same patient cohort.

Methods: One hundred fifty five children (125 former prematures originally participating in a prospective postnatal telemedical study with digital wide-field retinal imaging, and 30 age-matched term born children) were enrolled in the GRANIT study (Giessen RetinAl maturatioN study in former premature InfanTs) at 6-12 years. The premature participants were categorized by the results of the ROP-screening: prematures with laser-treated ROP (t-ROP; n=10), with spontaneously resolved ROP (sr-ROP; n=40), without ROP (no-ROP; n=75). In addition, they were categorized according to birth weight (BW) into <1000g, 1000-1500g, >1500g, and GA into ≤28 Weeks (W), >28 - ≤32 W, and >32 W.<br /> All participants underwent a comprehensive examination protocol, including orthoptic examination for strabismus, amblyopia, and refraction. VA was assessed with Landolt C and ETDRS letters, and LIS measured at 0°, 2,8° and 8° in the visual field using the MP1 (Nidek, Italy). Ophthalmological and neonatal intensive care parameters from the initial study were included in the analysis.

Results: Prevalence of strabismus and amblyopia was highest in the t-ROP group (50%, 20%) and lowest in the no-ROP group (17%, 9%). Participants in the t-ROP group were high myopic (mean refraction -4.4Dpt), while participants in no-ROP (mean refraction 0.62Dpt) and sr-ROP (mean refraction 0.75Dpt) were not. Central LIS (0°) was significantly lower in all groups except for BW >1500g (ANOVA, p<0.05). No significant differences were found for LIS at 2.8° and 8° in all groups. All children born ≤28W GA had significantly reduced VA. Multiple comparison test (Holm-Sidak or Dunn’s method) among the groups BW < 1000g or GA ≤28 W did not reveal significant treatment-related differences.

Conclusions: Prevalence of strabismus, amblyopia and refractive errors increase with severity of ROP, while low BW and GA were associated with significantly decreased central visual function, regardless of the severity of retinal changes. Central LIS and VA data correlate and increase the robustness of data sets describing foveal function.

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