March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
3-D Shape of Biomimetic Corneal Substitutes in the Living Human Eye
Author Affiliations & Notes
  • Jeb A. Ong
    Maisonneuve-Rosemont Hospital Research Centre, Montreal, Quebec, Canada
    Department of Ophthalmology,
    University of Montreal, Montreal, Quebec, Canada
  • Edouard Auvinet
    Maisonneuve-Rosemont Hospital Research Centre, Montreal, Quebec, Canada
    Computer Science and Operations Research,
    University of Montreal, Montreal, Quebec, Canada
  • Marie-Eve Choronzey
    Maisonneuve-Rosemont Hospital Research Centre, Montreal, Quebec, Canada
  • Neil Lagali
    Departments of Clinical and Experimental Medicine, and Ophthalmology, Linköping University, Linköping, Sweden
  • Per Fagerholm
    Departments of Clinical and Experimental Medicine, and Ophthalmology, Linköping University, Linköping, Sweden
  • May Griffith
    Departments of Clinical and Experimental Medicine, and Ophthalmology, Linköping University, Linköping, Sweden
  • Jean Meunier
    Maisonneuve-Rosemont Hospital Research Centre, Montreal, Quebec, Canada
    Computer Science and Operations Research,
    University of Montreal, Montreal, Quebec, Canada
  • Isabelle Brunette
    Maisonneuve-Rosemont Hospital Research Centre, Montreal, Quebec, Canada
    Department of Ophthalmology,
    University of Montreal, Montreal, Quebec, Canada
  • Footnotes
    Commercial Relationships  Jeb A. Ong, None; Edouard Auvinet, None; Marie-Eve Choronzey, None; Neil Lagali, None; Per Fagerholm, None; May Griffith, Ottawa Hospital Research Institute (P); Jean Meunier, None; Isabelle Brunette, None
  • Footnotes
    Support  CIHR, FRSQ Research in Vision Network
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 125. doi:https://doi.org/
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    • Get Citation

      Jeb A. Ong, Edouard Auvinet, Marie-Eve Choronzey, Neil Lagali, Per Fagerholm, May Griffith, Jean Meunier, Isabelle Brunette; 3-D Shape of Biomimetic Corneal Substitutes in the Living Human Eye. Invest. Ophthalmol. Vis. Sci. 2012;53(14):125. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To characterize the 3-D shape of corneas implanted with the first biomimetic corneal substitutes (BCS) and to compare this shape to that of normal corneas, based on the integrated analysis of Orbscan corneal topography average models (atlases).

Methods: : This study was conducted on 10 eyes of the first 10 subjects implanted with biomimetic corneal substitutes. All surgeries were performed by Dr. Per Fagerholm at the Linköping University Hospital, Sweden, between October and November 2007. Serial Orbscan II (Bausch and Lomb, Rochester, New York, USA) corneal topographies were performed on all eyes and several topography parameters were analyzed. Four-year follow-up was available for most subjects. Ten normal controls (spherical equivalent within ± 2.00 D and cylinder within ± 1.00 D from emmetropia) were matched for age and gender to each tested subject. 3-D atlases were constructed for the 10 BCS corneas and all 100 controls. Each atlas illustrated mean anterior elevation, mean posterior elevation and mean pachymetry. Difference maps and statistics maps were generated to compare the "BCS corneas" and "All controls" atlases.

Results: : Preliminary results show a smooth integration of the BCS surgical wound within the anterior surface profile, without significant steps or gaps. The Thinnest point was thinner (mean ± SEM: BCS: 266.22±29.88 µm; Controls: 570.86±4.03 µm; p < 0.001) and more inferiorly located (BCS: -1.04±0.24 mm from the center of the topography; Controls: -0.13±0.05 mm; p < 0.001) in BCS corneas, but did not seem to be displaced laterally (BCS: -0.21±0.29 mm, Controls: -0.42±0.04 mm; p = 0.1900). In the central 3.0 mm radius area, Surface irregularity (BCS: 8.81±1.15 D, Controls: 1.26±0.04 D; p < 0.001), Mean power (BCS: 49.23±1.92 D; Controls: 43.60±0.16 D; p <0.001) and Astigmatic power (BCS: 5.46±1.83 D; Controls: 0.74±0.05 D; p < 0.001) were increased in BCS corneas. Similar findings were observed in the annular 3.0-5.0 mm zone (p < 0.001).

Conclusions: : This comparative study will allow detailed characterization of the differences in shape between BCS corneas and corneas of normal emmetropic subjects matched for age and gender, in order to help optimize the shape of future BCS corneas.

Keywords: topography • transplantation • cornea: clinical science 
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