Abstract
Purpose: :
To ascertain the correlation of central corneal volume (CCV) using Scheimpflug imaging to central corneal thickness (CCT) using ultrasound pachymetry in normal eyes.
Methods: :
21 eyes without corneal disease were measured using a Scheimpflug camera and ultrasound pachymetry. CCV at 3mm, 5mm, and 7mm along with CCT were measured for all eyes.
Results: :
Linear regression analysis revealed strong correlation of 3mm CCV to ultrasound CCT (R=0.93). 88% of the change in CCV at 3mm was explained by CCT (R squared = 0.88). Similarly, strong correlations of CCV at 5mm and 7mm to ultrasound CCT were also suggested (R=0.94 and R=0.91, respectively). 88% of the change in CCV at 5mm and 83% of the change in CCV at 7mm were explained by CCT (R squared = 0.88 and R squared = 0.83, respectively). Further analysis showed similar findings for CCV at 3mm, 5mm, and 7mm when compared to Scheimpflug image derived CCT (R=0.98 and R squared = 0.97, R=0.96 and R squared = 0.92, and R=0.91 and R squared = 0.83, respectively).
Conclusions: :
Scheimpflug CCV appears to correlate linearly with both ultrasound and Scheimpflug CCT in normal eyes. Further study is needed to determine if CCV, derived from three dimensional data, can serve as a better surrogate for corneal turgescence than one dimensional CCT data.
Keywords: imaging/image analysis: clinical • cornea: clinical science • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)