March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
The Prevalence and Nature of Glaucomatous Defects in the Central 10° of the Visual Field
Author Affiliations & Notes
  • Ilana Traynis
    Psychology Department,
    Columbia University, New York, New York
  • Carlos G. De Moraes
    Ophthalmology, NYU School of Medicine, New York, New York
  • Ali S. Raza
    Psychology Department,
    Columbia University, New York, New York
  • Jeffrey M. Liebmann
    Ophthalmology, NYU School of Medicine, New York, New York
  • Robert Ritch
    Ophthalmology, New York Eye & Ear Infirmary, New York, New York
  • Donald C. Hood
    Psychology and Ophthalmology,
    Columbia University, New York, New York
  • Footnotes
    Commercial Relationships  Ilana Traynis, None; Carlos G. De Moraes, None; Ali S. Raza, None; Jeffrey M. Liebmann, Alcon Laboratories Inc. (C), Allergan Inc. (C), Carl Zeiss Meditec Inc. (C), Dyopsis Inc. (F, C), Merz Inc. (C), Pfizer Inc. (C), Quark Inc. (C), Topcon Medical Systems Inc. (F, C); Robert Ritch, Aeon Astron (C), Drais Pharmaceutical (C), Dyopsis Inc. (F), iSonic (C), Medacorp. (C), Ocular Instruments, Inc. (C), Topcon Medical Systems Inc. (F); Donald C. Hood, Topcon Medical Systems Inc. (F, C)
  • Footnotes
    Support  NIH Grant EY02115
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 194. doi:
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      Ilana Traynis, Carlos G. De Moraes, Ali S. Raza, Jeffrey M. Liebmann, Robert Ritch, Donald C. Hood; The Prevalence and Nature of Glaucomatous Defects in the Central 10° of the Visual Field. Invest. Ophthalmol. Vis. Sci. 2012;53(14):194.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To determine the prevalence and nature of visual field (VF) defects in the central 10° in glaucoma suspects (GS) and glaucoma patients using a prospective design.

Methods: : Glaucoma patients and GS with a 24-2 VF test (HFA, Zeiss, Inc) with a mean deviation (MD) better than -6dB were enrolled and tested with a 10-2 VF. Eyes were excluded from the study if either test was unreliable (fixation loss>33%, false positive or false negative>20%). The VF of the 66 eyes (50 patients) meeting these criteria were classified as abnormal if they had a cluster of at least 3 contiguous points (5%, 5%, 1% or 5%, 2%, 2%) on either the total deviation or pattern deviation plot. After adjusting the 10-2 test points to take into consideration the location of the ganglion cells,[1,2] the pattern of abnormal points was categorized as consistent with an arcuate-like nerve fiber bundle defect, a diffuse defect, or other.

Results: : There were nearly as many abnormal 10-2 VFs (66 hemifields, 46 eyes) as abnormal 24-2 VFs (68 hemifields, 45 eyes). Of the 64 normal hemifields on the 24-2 test, 10 (~16%) were abnormal based on the 10-2 test. [A similar number (~18%) of hemifields with normal 10-2 tests were abnormal on the 24-2 test.] Of the 66 abnormal hemifields on the 10-2 test, 43 (~65%) were consistent with an arcuate-like nerve fiber bundle defect. Of the remaining 23 abnormal hemifields, 8 were diffuse and 15 other (e.g. temporal defect or scattered points).

Conclusions: : The 10-2 VF was abnormal in about as many eyes/hemifields as was the 24-2 VF [3], including 16% of the hemifields with normal 24-2 tests. The majority of the 10-2 VF abnormalities were consistent with an arcuate-like nerve fiber bundle defect. For glaucoma screening, both the 10-2 and 24-2 tests, or a customized pattern that combines the 6° grid of the 24-2 with a greater number of points in the central 10°, should be used.[4] 1. Hood DC et al. IOVS 2011, 940-946; 2. Drasdo N et al. Vision Res 2007, 2901-2911; 3. Langerhost CT et al. Perimetry Update 1996/1997, 67-73; 4. Schiefer U et al, IOVS 2010, 5685-5689.

Keywords: visual fields • macula/fovea • nerve fiber layer 
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