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Philip Maier, Sonja Heinzelmann, Philipp Eberwein, Florian Birnbaum, Daniel Böhringer, Thomas Reinhard; Clinical Results After Descemet Membrane Endothelial Keratoplasty vs. Penetrating Keratoplasty. Invest. Ophthalmol. Vis. Sci. 2012;53(14):64.
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© ARVO (1962-2015); The Authors (2016-present)
To report results and complications following descemet membrane endothelial keratoplasty (DMEK) in comparison to penetrating keratoplasty (PKP).
We reviewed the charts of all patients undergoing DMEK surgery in 2011 for visual acuity and complications and compared these to a historical control group of PKP. Graft survival was assessed by means of the Kaplan-Meier method. We logarithmized visual acuity for summary statistics.
Visual acuity averaged -0.89±0.78 logMAR before DMEK and -0.82±0.49 logMAR before PKP. Patients were followed in mean 49.6±42.2 days following DMEK and 469.2±313 days following PKP. Visual acuity at last follow up visit averaged -0.47±0.62 logMAR after DMEK and -0.47±0.46 afer PKP. 65% of patients after DMEK as well as after PKP reached a visual acuity >=0.5, whereas 40% after DMEK and 22% after PKP reached a visual acuity of >=0.8. A second surgical intervention after DMEK was necessary in 22% of the patients after DMEK (24% after PKP) and 14% of the grafts suffered failure after DMEK compared to 16% after PKP. Endothelial cell density averaged 1257+/520cells/mm2 after DMEK and 1497±522cell/mm² after PKP.
DMEK is a promising method for curing diseases of the corneal endothelium, reaching a much faster visual recovery compared to PKP. However, longer follow up is required to assess longevity of the grafts.
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