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Angelo P. Tanna, Daniel Sarezky, Theodore Krupin, Charles W. Stewart, Aaron Cohen, Nicholas J. Volpe; Correlation Between Inter-eye Difference In Visual Field Global Index Values And Pupillary Response As Measured By An Automated Pupillometer In Subjects With Glaucoma. Invest. Ophthalmol. Vis. Sci. 2012;53(14):211.
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To evaluate the effectiveness of a new binocular infrared computerized pupillometer in the quantitative measurement of the afferent pupillary response in patients with glaucoma by assessing the correlation of the inter-eye difference in visual function versus the inter-eye difference in the afferent papillary response.
Twenty-three patients with primary open-angle glaucoma underwent examination with a prototype, automated, binocular pupillometer. Within nine months of pupillography, all patients underwent automated static perimetry using the Humphrey Field Analyzer IIi, 24-2, Swedish Interactive Threshold Algorithm. Correlations between the inter-eye difference in the afferent pupillary response and the inter-eye difference in mean deviation (MD) and pattern standard deviation (PSD) were explored.
There was a strong correlation between the inter-eye difference in the afferent pupillary response and the inter-eye difference in MD (r = -0.77 (Spearman correlation coefficient), p < 0.001) and PSD (r = 0.57, p = 0.01).
A new, binocular computerized pupillometer provides a rapid and convenient method for the quantitative assessment of the afferent pupillary response. The inter-eye asymmetry in the pupil response correlates strongly with visual field asymmetry in patients with glaucoma.
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