March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
The Relationship Between Visual Field Parameters and Retrobulbar Blood Flow in Patients with Glaucoma
Author Affiliations & Notes
  • Melanie A. Pickett
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • Alon Harris
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • Brent A. Siesky
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • Darrell WuDunn
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • Annahita Amireskandari
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • Sandy Ngo
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • Erin Stewart
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • Louis B. Cantor
    Ophthalmology, Eugene & Marilyn Glick Eye Inst, Indianapolis, Indiana
  • Joanna Wierzbowska
    Ophthalmology, Military Institute of Medicine , Warsaw, Poland
  • John Abrams
    Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana
  • Footnotes
    Commercial Relationships  Melanie A. Pickett, None; Alon Harris, Pfizer (C); Brent A. Siesky, None; Darrell WuDunn, None; Annahita Amireskandari, None; Sandy Ngo, None; Erin Stewart, None; Louis B. Cantor, None; Joanna Wierzbowska, None; John Abrams, None
  • Footnotes
    Support  Unrestricted grant from Research to Prevent Blindness and Pfizer Pharmaceuticals
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 244. doi:
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      Melanie A. Pickett, Alon Harris, Brent A. Siesky, Darrell WuDunn, Annahita Amireskandari, Sandy Ngo, Erin Stewart, Louis B. Cantor, Joanna Wierzbowska, John Abrams; The Relationship Between Visual Field Parameters and Retrobulbar Blood Flow in Patients with Glaucoma. Invest. Ophthalmol. Vis. Sci. 2012;53(14):244.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To investigate the relationship between the change in visual field parameters and retrobulbar blood flow after two years in patients with open angle glaucoma (OAG).

Methods: : 100 OAG patients were examined at baseline and following 2 years follow up for visual field parameters and retrobulbar blood flow. Associations between the changes in visual field and blood flow parameters were evaluated using Pearson correlation coefficients. In addition, to explore gender specific relationships, correlations were calculated separately for 58 females and 42 males.

Results: : In the entire cohort of patients with OAG, central retinal artery (CRA) peak systolic velocity (PSV) and end diastolic velocity (EDV) is positively correlated to mean deviation (MD) (r=0.20, p=0.0416; r=0.22, p=0.0273). CRA EDV is negatively correlated to advanced glaucoma intervention study (AGIS) score (r=-0.26, p=0.0099).In the gender specific analysis, CRA PSV is positively correlated to MD in females (r=0.31, p=0.0175) but not males (r=-0.01, p=0.93). CRA EDV is positively correlated to MD (r=0.39, p=0.0020) and negatively correlated to AGIS score (r=-0.34, p 0.0082) in females, but again not associated in males (r=-0.08 for MD and r=-0.13 for AGIS score).

Conclusions: : In this cohort of patients with OAG, as CRA PSV and CRA EDV increased the visual field MD value also increased during 2 years follow up. When CRA EDV increased OAG patients AGIS score decreased. Thus, increased retinal blood flow has a positive relationship with visual function as defined by MD and AGIS score. Although these associations were significant when evaluating all subjects, the significance was driven by the relationships in females, with weak or no associations found in male subjects with OAG.

Keywords: visual fields • blood supply • clinical (human) or epidemiologic studies: risk factor assessment 
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