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Annahita Amireskandari, Alon Harris, Brent A. Siesky, Rita Ehrlich, Yochai Z. Shoshani, Louis B. Cantor, Barbara M. Wirostko, Sandy Ngo, Chris Jonescu Jonescu, Hanna J. Garzozi; Baseline Retrobulbar Blood Flow is Predictive of Macular Thickness in Patients with Glaucoma. Invest. Ophthalmol. Vis. Sci. 2012;53(14):250.
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© ARVO (1962-2015); The Authors (2016-present)
To examine if baseline retrobulbar blood flow as measured by color Doppler imaging (CDI) is predictive of macular thickness in patients with open angle glaucoma (OAG).
CDI and optical coherence tomography (OCT) parameters at baseline were analyzed as predictors of macular thickness after 2 years of follow up using Pearson correlation coefficients.
In 100 patients with OAG, baseline retrobulbar blood flow parameters were a positively correlated with 2-year macular thickness measurements as assessed with OCT. Ophthalmic artery (OA) end diastolic velocity (EDV) at baseline was positively correlated with 2-year inner superior macular thickness (r=0.20, p=0.0493). Central retinal artery (CRA) peak systolic velocity (PSV) at baseline was positively correlated with 2-year outer superior macular thickness (r=0.25, p=0.0106), inner superior macular thickness (r=0.27, p=0.0062), superior outer nasal macular thickness (r=0.33, p=0.0008), inner nasal macular thickness (r=0.23, p=0.0204), and macular volume (r=0.24, p=0.0149). CRA EDV at baseline was positively correlated with 2-year outer superior macular thickness (r=0.28, p=0.0039) and superior outer nasal macular thickness (r=0.30, p=0.0024). Nasal posterior ciliary artery (NPCA) EDV at baseline was positively correlated with 2-year outer superior macular thickness (r=0.21, p=0.034), outer inferior macular thickness (r=0.21, p=0.0368), and outer nasal macular thickness (r=0.21, p=0.0325).
In this cohort of patients with OAG, baseline retrobulbar blood flow, as measured by CDI, is a predictor of 2-year macular thickness measurements. A positive correlation was found between baseline retrobulbar blood flow and 2-year macular thickness parameters which indicates that high retrobulbar blood flow at baseline predicts larger macular thickness after 2 years.
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