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Sally Primus, Alon Harris, Brent A. Siesky, Melanie A. Pickett, Ingrida Januleviciene, Sandy Ngo, Annahita Amireskandari, Chi-Wah R. Yung, John Abrams, Miriam Zalish; Relationship Between Retinal Capillary Blood Flow and Visual Acuity in Patients with Glaucoma: Differences in Males and Females. Invest. Ophthalmol. Vis. Sci. 2012;53(14):256.
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To examine the gender specific differences in the associations between changes over a two-year period in retinal capillary blood flow and visual acuity (VA) in patients with open angle glaucoma (OAG).
Female (n=25) and male (n=25) patients with OAG were analyzed for retinal capillary blood flow using confocoal scanning laser Doppler and VA at baseline and after 2 years follow up. Total retinal capillary blood flow was divided into 10, 25, 50, 75 and 90 percentiles of total flow. Associations between the changes in retinal capillary blood flow and VA were evaluated using Pearson correlation coefficients separately for female and male patients.
In females, change in logMAR VA score was positively correlated to change in the superior 10th% sector blood flow (r=0.51, p=0.008), superior 25th% sector blood flow (r=0.56, p=0.003), superior 50th% sector blood flow (r=0.62, p=0.001), superior 75th% sector blood flow (r=0.62, p=0.001), superior 90th% sector blood flow (r=0.61, p=0.001), and superior mean flow (r=0.58, p=0.002) over a two-year interval as measured by HRF. These associations were not found males (correlations ranging from -0.08 to 0.05), and were significantly lower than the correlations found in females (p<0.05). However, the change in logMAR VA score from baseline for males was larger than females (p=0.0021), with a 20% increase for females and a 440% increase for males. No significant changes from baseline to two-year measurements and no significant sex differences were observed for superior sector blood flow.
In females with OAG, an increase in logMAR VA score was positively correlated with a rise superior segment blood flow over a two-year interval. Conversely, such a correlation was not found in males with OAG. Despite having similar changes in superior segment retinal blood flow over two years, females had better logMAR VA scores at the 2 year follow up.
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