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Gustavo V. De Moraes, Jeffrey M. Liebmann, Robert Ritch, Joseph L. Simonson, Christopher Bowd, Pamela A. Sample, Christopher A. Girkin, Felipe A. Medeiros, Robert N. Weinreb, Linda M. Zangwill; African Descent and Glaucoma Evaluation Study (ADAGES): Ancestry Differences in Regional Rates of Visual Field Change in Eyes with Glaucomatous Optic Neuropathy. Invest. Ophthalmol. Vis. Sci. 2012;53(14):263.
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Individuals of European (ED) and African (AD) descent have been shown to differ significantly with respect to topographic structural and functional measurements.[1,2] We investigated differences in regional rates of visual field (VF) change between eyes of people of ED and AD eyes with glaucomatous optic neuropathy (GON).
This was an observational cohort study including 842 eyes of 443 patients (273 ED and 170 AD) recruited from the Diagnostic Innovations in Glaucoma Study (DIGS) and the African Descent and Glaucoma Study (ADAGES). We included eyes with GON with at least 5 standard automated perimetry VF tests (SITA 24-2 strategy). To asses topographic rates of progression, we divided the 24-2 VF test output into 6 regions based on the Garway-Heath map. Rates of VF change (dB/yr) were calculated using linear regression with ordinary least square estimates providing the slopes (rate of change) and their statistical significance (P-value) for each region. Significant progression was defined if the regional slopes were worse than -1.0 dB/yr at P <0.01. We compared the mean regional slopes and the number of eyes meeting the progression definition between ED and AD groups.
The mean ± SD for the number of VF tests was 10.5±3.8 and 9.4±3.4 for ED and AD eyes respectively (P0.25, GEE). The number of VF regions meeting the progression definition also did not differ between groups (all P-values >0.10, Fisher’s exact test).
Consistent with our previous report assessing global rates of change (MD and VFI), ED and AD patients with GON do not show significant differences in regional rates of progressive VF loss.
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