March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Retinal Vascular Caliber Changes on OCT after Intravitreal Bevacizumab Injection in Diabetic Macular Edema
Author Affiliations & Notes
  • Sung Soo Kim
    Ophthalmology, Yonsei Univ Gangnam Sev Hosp, Seoul, Republic of Korea
  • Hyeong Eun Kim
    Ophthalmology, Yonsei Univ Gangnam Sev Hosp, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships  Sung Soo Kim, None; Hyeong Eun Kim, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 345. doi:
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    • Get Citation

      Sung Soo Kim, Hyeong Eun Kim; Retinal Vascular Caliber Changes on OCT after Intravitreal Bevacizumab Injection in Diabetic Macular Edema. Invest. Ophthalmol. Vis. Sci. 2012;53(14):345.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To investigate retinal vascular caliber changes with Spectral Domain OCT after intravitreal Bevacizumab injection in diabetic macular edema patients

Methods: : 34 eyes of 29 diabetic macular edema patients who were injected Bevacizumab(1.25g/0.05ml) intravitreously were studied. 24 fellow eyes of 24 patients with Bevacizumab injection were also recruited as a control group. We measured retinal vascular caliber at 0.5~1 disc size apart from disc margin with Spectral Domain OCT at the baseline, 1 month and 3 months follow-up visits. Central macular thicknesses were also measured.

Results: : Over the 3 months of studies, there was a significant reduction of arteriolar caliber at 3 months compared to baseline (p=0.024), There were significant reduction of venular caliber at 1 month(p=0.001) and 3 months(p=0.000) compared to baseline. Venymliular caliber reduction at 3 months follow-up was significantly correlated with central macular thickness(R=0.487, p=0.003).

Conclusions: : Retinal venular caliber reduction was significant at 1 and 3 months follow-up and arteriolar caliber reduction was significant at 3 months follow-up compared to baseline. After 3 months of treatment, venular caliber reduction was correlated with reduction of central macular thickness.

Keywords: diabetic retinopathy • macula/fovea • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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