March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Retinal Function In Patients With Isquemic Diabetic Retinopathy Using Full-field Electroretinogram
Author Affiliations & Notes
  • Mariana A. Coelho
    Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil
  • Sung E. Watanabe
    Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil
  • Somaia Mitne
    Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil
  • Luciana C. Noia
    Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil
  • Adriana Berezovsky
    Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil
  • Augusto Paranhos, Jr.
    Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil
  • Footnotes
    Commercial Relationships  Mariana A. Coelho, None; Sung E. Watanabe, None; Somaia Mitne, None; Luciana C. Noia, None; Adriana Berezovsky, None; Augusto Paranhos, Jr., None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 374. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Mariana A. Coelho, Sung E. Watanabe, Somaia Mitne, Luciana C. Noia, Adriana Berezovsky, Augusto Paranhos, Jr.; Retinal Function In Patients With Isquemic Diabetic Retinopathy Using Full-field Electroretinogram. Invest. Ophthalmol. Vis. Sci. 2012;53(14):374.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : Evaluate full-field electroretinogram findings in patients with isquemic diabetic retinopathy and correlate with visual prognosis

Methods: : A group of 30 patients with pre-proliferative and proliferative diabetic retinopathy without previous photocoagulation had retinal function evaluated by full-field electroretinography according to the International Society for Clinical Electrophysiology of Vision standard protocol. The responses analyzed were: scotopic rod response, scotopic maximal response, scotopic response for oscillatory potentials, photopic single-flash response and photopic 30Hz flicker for cone response.

Results: : 30 eyes of diabetic retinopathy group and 20 eyes of subjects without diabetes were randomly selected. Mean age of diabetic retinopathy group (± 1 SD) was 53.56 ± 9.91 years. The mean time of the diagnosis of diabetes was 13.96 years. Mean values amplitude for rod response was 184.23 ± 62.29 µV, 322.47 ± 93.76 µV for maximal response; 59.02 ± 38.04 µV for oscillatory potentials; 84.15 ± 38.19 µV for single-flash cone response and 59.43 ± 23.55 µV for light adapted 30 Hz flicker response. Mean values b-wave implicit time was 97.48 ± 11.02 ms for rod response; 35.81 ± 6.02 ms for single-flash cone response and 36.18 ± 6.39 ms for 30 Hz flicker response. No statistically difference was found between the groups for rod response, maximal response, cone response and amplitude of light adapted 30 Hz flicker response by gender. Statistically significant difference (p-value < 0,001) was found between the diabetic retinopathy group and the normal group in oscillatory potentials and also b-waves implicit times for rod response, cone response and flicker response. Diabetic patients with more severe condition, as vitreous hemorrhage and tractional retinal detachment (5 patients) had lower responses for oscillatory potentials (4 patients), maximal response (4 patients) and cone response (5 patients) when comparing to normal group.

Conclusions: : The oscillatory potentials derive from the inner plexiform layers involving bipolar cells, amacrine cells and ganglion cells which are also involved in the physiopathology of the diabetic retinopathy. These findings suggest that changes in the oscillatory potentials and b-waves implicit times in the diabetic retinopathy may be the first sign of injury of the retina in this disease. Furthermore, an increased degree of loss in amplitude of oscillatory potentials may be a distinctive feature of diabetic retinopathy with poor visual prognosis.

Keywords: electroretinography: clinical • diabetic retinopathy 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×