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Yuki Muraoka, Tomoaki Murakami, Kazuaki Nishijima, Tadamichi Akagi, Akihito Uji, Takahiro Horii, Naoko Ueda-Arakawa, Munemitsu Yoshikawa, Akitaka Tsujikawa, Nagahisa Yoshimura; Association between Retinal Venular Dilation and Foveal Serous Retinal Detachment in Diabetic Macular Edema. Invest. Ophthalmol. Vis. Sci. 2012;53(14):407.
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© ARVO (1962-2015); The Authors (2016-present)
Despite its clinical relevance, it remains ill-defined how retinal vessel diameters are associated with diabetic macular edema (DME). Here we investigated the relationship between retinal vascular calibers and qualitative and quantitative parameters in spectral-domain optical coherence tomography (SD-OCT) in eyes with DME.
We retrospectively reviewed consecutive 108 eyes of 80 patients with clinically significant macular edema on which SD-OCT and color fundus photograph were performed on the same day. We assessed retinal thickness in individual areas in Early Treatment Diabetic Retinopathy Study (ETDRS) grid and foveal pathomorphologies on OCT images obtained by Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany). The diameters of superotemporal or inferotemporal retinal vessels from the optic disc were calculated with a computer-assisted technique (IVAN, University of Wisconsin, Madison).
Inferotemporal venules, which had a larger diameter than the superotemporal venules (137.0 ± 21.2μm vs. 128.3 ± 16.4μm; p<0.001), was specifically associated with diastolic blood pressure and low density lipoprotein. There were positive relationship between inferotemporal venular diameters and retinal thickness in the inferior, superior, and temporal subfields in the perifovea (p = 0.001, p = 0.041, and p = 0.047, respectively). Superotemporal venular diameters were also positively associated with retinal thickness in the superior and inferior subfields (p = 0.010 and p = 0.011, respectively). Although retinal thickness in the central subfield were not at all correlated to retinal vessel diameters, eye with serous retinal detachment (SRD) at the fovea had larger diameters in the superotemporal and inferotemporal venules than those without SRD (p = 0.002 and p = 0.003, respectively).
Dilated retinal venules had significant association with retinal thickness in the perifovea and SRD at the fovea in DME.
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