March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Fluorescein Angiography And SD-OCT Analysis Of Lasered Microaneurysms In Diabetic Macular Edema
Author Affiliations & Notes
  • Su-Na Lee
    Ophthalmology, Shiley Eye Center, UCSD, La Jolla, California
  • Jay Chhablani
    Ophthalmology, Shiley Eye Center, UCSD, La Jolla, California
  • Haiyan Wang
    Ophthalmology, Shiley Eye Center, UCSD, La Jolla, California
  • Giulio Barteselli
    Ophthalmology, Shiley Eye Center, UCSD, La Jolla, California
  • Sharif El Emam
    Ophthalmology, Shiley Eye Center, UCSD, La Jolla, California
  • Igor Kozak
    Ophthalmology, Shiley Eye Center, UCSD, La Jolla, California
  • Lingyun Cheng
    Ophthalmology, Shiley Eye Center, UCSD, La Jolla, California
  • William R. Freeman
    Ophthalmology, Shiley Eye Center, UCSD, La Jolla, California
  • Footnotes
    Commercial Relationships  Su-Na Lee, None; Jay Chhablani, None; Haiyan Wang, None; Giulio Barteselli, None; Sharif El Emam, None; Igor Kozak, None; Lingyun Cheng, None; William R. Freeman, None
  • Footnotes
    Support  NIH grants R01EY007366 and R01EY018589 (WRF), R01EY016323 (DUB) and R01EY020617 (LC), "RPB incorporated and unrestricted funds from Jacobs Retina Center"
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 408. doi:
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      Su-Na Lee, Jay Chhablani, Haiyan Wang, Giulio Barteselli, Sharif El Emam, Igor Kozak, Lingyun Cheng, William R. Freeman; Fluorescein Angiography And SD-OCT Analysis Of Lasered Microaneurysms In Diabetic Macular Edema. Invest. Ophthalmol. Vis. Sci. 2012;53(14):408.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To investigate the changes of microaneurysms (MAs) and to evaluate the closure rate of MAs on fluorescein angiography (FA) and spectral domain optical coherence tomogram (SD-OCT) after navigated focal laser photocoagulation in eyes with diabetic macular edema (DME).

Methods: : We investigated 16 eyes of 12 patients treated with navigated retinal laser photocoagulator Navilas® (OD-OS, Teltow, Germany) for DME . The eyes that underwent simultaneous FA and SD-OCT (Spectralis, Heidelberg Engineering, Vista, CA) at baseline and after photocoagulation, were included. Ninety-seven raster scans per eye were used to detect the change of MAs at the same location after photocoagulation. Baseline FA leakage score (0=no leakage, 1=mild leakage, 2=severe leakage), SD-OCT characteristics (MA size, location, retinal thickness) and closure rate of MAs after photocoagulation were analyzed by two masked observers.

Results: : Seventy nine MAs were analyzed and mean follow up period after photocoagulation was 8.65 month. At baseline, mean FA leakage score was 1.38 ± 0.56 and average MA size was 92.83 ± 31.37 μm. Most of MAs (68.35%) were located at the inner nuclear and inner plexiform layers. After photocoagulation, mean retinal thickness decreased by 74.79 ± 119.78 μm (p<0.0001), and the percentage of closed MAs was 82.28 % on SD-OCT and 77.22 % on FA. The closure rate of MAs by OCT was negatively associated with the size of MAs (p=0.001).

Conclusions: : The changes of MAs after navigated focal laser photocoagulation could be studied on simultaneous FA and SD-OCT. Percentage of closed MAs was 82.28 % and 77.22 % on SD-OCT and FA, respectively. The closure rate of MAs was negatively associated with the size of MAs in eyes with DME.

Keywords: diabetic retinopathy • edema • laser 
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