March 2012
Volume 53, Issue 14
ARVO Annual Meeting Abstract  |   March 2012
Morphological Retina Responses Post Laser Photocoagulation In Centre Involving Diabetic Macular Oedema(dmo)
Author Affiliations & Notes
  • Ling Zhi Heng
    Institute of Ophthalmology, London, United Kingdom
  • Ramu Muniraju
    King's College Hospital, London, United Kingdom
  • Rahmi Akshikar
    King's College Hospital, London, United Kingdom
  • Sobha Sivaprasad
    Ophthalmology, King's College Hospital, London, London, United Kingdom
  • Footnotes
    Commercial Relationships  Ling Zhi Heng, None; Ramu Muniraju, None; Rahmi Akshikar, None; Sobha Sivaprasad, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 414. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Ling Zhi Heng, Ramu Muniraju, Rahmi Akshikar, Sobha Sivaprasad; Morphological Retina Responses Post Laser Photocoagulation In Centre Involving Diabetic Macular Oedema(dmo). Invest. Ophthalmol. Vis. Sci. 2012;53(14):414.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Purpose: : This study is done to evaluate the short and long term effects of laser photocoagulation in patients with centre involving diabetic macular oedma(DMO).

Methods: : We evaluated 30 patients at baseline, 4 to 6 months and 12 months with centre involving DMO that responded to macular laser therapy as proven with improved visual acuity(VA) or decreased central subfield thickness(CST) on spectralis OCT at 12 months. Changes in the following quantitative and qualitative parameters were evaluated at the 2 time points, namely, CST, macular volume, presence or absence of fine exudates, clumped exudates, inner segment/outer segment(IS/OS), external limiting membrane(ELM), outer retina cysts(large, medium, small), inner retina cysts(large, medium,small), nerve fiber layer cysts, change in pattern of DMO( cystoid, diffuse, mixed, subretina detachment(SRD)) were evaluated. Results were tabulated using SPSS ver 17.0, using independent T tests, and crosstabulated using chi-square tests. P<0.05 were considered significant for our study.

Results: : None of the quantitative or qualitative parameters changes significantly at 4 months except for the disappearance of large inner retinal cysts. However, at 12 months, there was a significant decrease in CST(p<0.001); decrease in both fine and clumped exudates(P=0.002, p=0.001), disappearance in both large inner and outer retina cysts(p=0.007,p=0.018) and significant improvement in patients with preserved ELM(p=0.007). That may explain the delayed improvement in VA with laser. The morphological pattern of diffuse and cystoid oedema at baseline did not influence the final outcome of laser treatment.(p=0.679,p=0.663)

Conclusions: : The study suggests that laser photocoagulation should still bet he first line treatment for centre involving macular oedema but the beneficial effects on macular morphology is delayed up to 12 months.

Keywords: diabetic retinopathy • imaging/image analysis: clinical 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.