March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Osmolarity in Patients with Meibomian Gland Dysfunction (MGD)
Author Affiliations & Notes
  • Elisabeth M. Messmer
    Dept of Ophthalmology, Ludwig Maximilians University, Munich, Germany
  • Jennifer Drillisch
    Dept of Ophthalmology, Ludwig Maximilians University, Munich, Germany
  • Anselm Kampik
    Dept of Ophthalmology, Ludwig Maximilians University, Munich, Germany
  • Footnotes
    Commercial Relationships  Elisabeth M. Messmer, None; Jennifer Drillisch, None; Anselm Kampik, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 556. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Elisabeth M. Messmer, Jennifer Drillisch, Anselm Kampik; Osmolarity in Patients with Meibomian Gland Dysfunction (MGD). Invest. Ophthalmol. Vis. Sci. 2012;53(14):556.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To study tear film (TF) osmolarity in patients with obstructive MGD.

Methods: : 27 normal probands (17 female, 21-48 years, mean age 29 years) and 30 patients with MGD (15 female, 31-80 years, mean age 60 years) underwent VA testing, OSDI questionnaire, slit lamp examination, ocular surface staining, TF-BUT measurements, and Schirmer testing with anesthesia. Prior to all invasive procedures, TF osmolarity was determined in both eyes using the TearLab® osmometer. Maximal / mean TF osmolarities were recorded. Statistics were performed using Chi-Square- and Mann-Whitney-U-tests.

Results: : In patients with MGD, mean and maximal TF osmolarities were 298.6 (+/-17.6) mOsmol/L and 303.5 (+/-18.8) mOsmol/L, respectively. In probands, mean TF osmolarities of 289.7 (+/- 7,5) mOsmol/L, and maximal values of 293.4 (+/-10.1) mOsmol/L were measured. Maximal as well as mean TF osmolarities significantly differentiated between normal probands and patients with MGD (p=0.018 and p=0.03, respectively), TF osmolarity correlated to TF-BUT (p=0.007), Schirmer test (p=0.004), conjunctival (p=0.016) as well as corneal (p=0.05) staining. No significant correlation was evident to OSDI, percentage of obstructed meibomian gland orifices, quality of meibom, and age.

Conclusions: : TF osmolarity as measured with the Tearlab® osmometer is significantly increased in patients with MGD and correlates with some clinical tests.

Keywords: cornea: tears/tear film/dry eye • conjunctiva • cornea: epithelium 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×