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Elisabeth M. Messmer, Jennifer Drillisch, Anselm Kampik; Osmolarity in Patients with Meibomian Gland Dysfunction (MGD). Invest. Ophthalmol. Vis. Sci. 2012;53(14):556.
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© ARVO (1962-2015); The Authors (2016-present)
To study tear film (TF) osmolarity in patients with obstructive MGD.
27 normal probands (17 female, 21-48 years, mean age 29 years) and 30 patients with MGD (15 female, 31-80 years, mean age 60 years) underwent VA testing, OSDI questionnaire, slit lamp examination, ocular surface staining, TF-BUT measurements, and Schirmer testing with anesthesia. Prior to all invasive procedures, TF osmolarity was determined in both eyes using the TearLab® osmometer. Maximal / mean TF osmolarities were recorded. Statistics were performed using Chi-Square- and Mann-Whitney-U-tests.
In patients with MGD, mean and maximal TF osmolarities were 298.6 (+/-17.6) mOsmol/L and 303.5 (+/-18.8) mOsmol/L, respectively. In probands, mean TF osmolarities of 289.7 (+/- 7,5) mOsmol/L, and maximal values of 293.4 (+/-10.1) mOsmol/L were measured. Maximal as well as mean TF osmolarities significantly differentiated between normal probands and patients with MGD (p=0.018 and p=0.03, respectively), TF osmolarity correlated to TF-BUT (p=0.007), Schirmer test (p=0.004), conjunctival (p=0.016) as well as corneal (p=0.05) staining. No significant correlation was evident to OSDI, percentage of obstructed meibomian gland orifices, quality of meibom, and age.
TF osmolarity as measured with the Tearlab® osmometer is significantly increased in patients with MGD and correlates with some clinical tests.
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