March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Long-term Treatment with Nutritional Supplements Containing Gamma Linolenic Acid and Omega 3 Fatty acids Improve Moderate to Severe Keratoconjunctivitis Sicca
Author Affiliations & Notes
  • John D. Sheppard, Jr.
    Ophthalmology, Eastern Virginia Medical Sch, Norfolk, Virginia
  • Stephen C. Pflugfelder
    Ophthal-Ocular Surf Ctr,
    Baylor College of Medicine, Houston, Texas
  • Ruhi Singh
    Cullen Eye Institute,
    Baylor College of Medicine, Houston, Texas
  • Andrew J. McClellan
    Ophthalmology,
    Baylor College of Medicine, Houston, Texas
  • Mitchell P. Weikert
    Ophthalmology,
    Baylor College of Medicine, Houston, Texas
  • Stephen V. Scoper
    Virginia Eye Consultants, Norfolk, Virginia
  • Thomas J. Joly
    Virginia Eye Consultants, Norfolk, Virginia
  • Dayna M. Lago
    Virginia Eye Consultants, Norfolk, Virginia
  • Walter O. Whitley
    Virginia Eye Consultants, Norfolk, Virginia
  • Footnotes
    Commercial Relationships  John D. Sheppard, Jr., Science Based Health (R); Stephen C. Pflugfelder, Science Based Health (R); Ruhi Singh, None; Andrew J. McClellan, None; Mitchell P. Weikert, None; Stephen V. Scoper, None; Thomas J. Joly, None; Dayna M. Lago, None; Walter O. Whitley, None
  • Footnotes
    Support  Science Based Health, Houston, TX
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 581. doi:https://doi.org/
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      John D. Sheppard, Jr., Stephen C. Pflugfelder, Ruhi Singh, Andrew J. McClellan, Mitchell P. Weikert, Stephen V. Scoper, Thomas J. Joly, Dayna M. Lago, Walter O. Whitley; Long-term Treatment with Nutritional Supplements Containing Gamma Linolenic Acid and Omega 3 Fatty acids Improve Moderate to Severe Keratoconjunctivitis Sicca. Invest. Ophthalmol. Vis. Sci. 2012;53(14):581. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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  • Supplements
Abstract

Purpose: : Patients with mild, moderate or severe dry eye continue to require multiple therapeutic interventions. Patients with meibomian gland dysfunction (MGD) often suffer from evaporative tear loss, as evidenced by accelerated tear film break up time and increased lactoferrin tear concentration. Nutritional supplementation, particularly, gamma linolenic acid (GLA) and omega 3 fatty acids may improve MGD and secretion contents. In this study, the efficacy of a nutritional supplement containing GLA and omega 3 fatty acids taken daily for 6 months was evaluated for treatment of post-menopausal patients with moderate to severe keratoconjunctivitis sicca.

Methods: : This randomized, double-blind, placebo-controlled, prospective clinical trial was conducted at two sites with multiple investigators. A total of 36 enrolled subjects were either given nutritional supplements (HydroEye®, ScienceBased Health, Houston, TX, n=17) or placebo (n=19) for a period of 6 months. Subjects were evaluated at baseline, 4, 12 and 24 wks for ocular surface disease index (OSDI) scores, Schirmer test, tear breakup time (TBUT), conjunctival and corneal staining. Conjunctival impression cytologies were also obtained and were stained for HLA-DR and CD11c.

Results: : After 24 wks, patients reported a significant improvement in irritation symptoms, with an average OSDI score of 34±5 after placebo treatment (n=19) compared to 21±4 after supplement treatment (n=17, p=0.05). After 24 wks placebo treatment, dendritic cell HLA-DR staining increased significantly by 36±9% and integrin staining (CD11c) also increased significantly by 34±7% when compared to supplement treatment (n=19/group, p<0.001). Neither treatment had any effect on tear flow, TBUT, conjunctival or corneal staining.

Conclusions: : Significant improvement in self reported patient assessments as well as inflammatory biomarkers indicate that nutritional supplementation over time improves the signs and symptoms of evaporative dry eye and thereby MGD. In this study, a specifically formulated oral nutritional preparation for the treatment of dry eye was shown to be beneficial, particularly in patients with imbalanced diets.

Clinical Trial: : http://www.clinicaltrials.gov NCT00883649

Keywords: nutritional factors • cornea: tears/tear film/dry eye 
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