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Reetika Sharma, Harsh I. Singh, Sat P. Garg, Pradeep Venkatesh, Rohit Saxena, Tanuj Dada; Evaluation of the Effect of Pan Retinal Photocoagulation on Optic Nerve Head parameters using HRT 3. Invest. Ophthalmol. Vis. Sci. 2012;53(14):652.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the optic disc topography after Pan Retinal Photocoagulation (PRP) in diabetic retinopathy patients using Confocal Scanning Laser Ophthalmoscopy (HRT3).
Twenty two eyes of 22 diabetic patients (NIDDM) underwent PRP for proliferative diabetic retinopathy. Subjects with glaucoma or family history of glaucoma, any co- existing neuro-ophthalmic disease, uveitis, retinal artery or vein occlusion, anterior segment abnormality that could affect IOP (eg exfoliation, pigment dispersion, corneal opacity) or lasered previously were excluded from the study. Optic Nerve Head (ONH) of these patients were evaluated by Confocal Scanning Laser Ophthalmoscopy (HRT3) at baseline, 3 and 6 months following completion of PRP. The global values of ONH parameters were compared between baseline versus 3 months and baseline versus 6 months using Wilcoxon Signed Ranks Test.
There were 15 males and 7 females with mean age of 49.8 yrs (36yrs-66yrs). The mean intraocular pressure was 13.1±2.6 mm Hg at baseline, 13.4±2.6 mm Hg at 3 months and 13.3±2.2 mm Hg at 6 months (p = 0.378 between baseline and 3 months; p = 0.605 between baseline and 6 months). The global values of ONH parameters did not show any significant change from baseline to 3 months. At 6 months there was a significant increase in cup area (p=0.018), cup:disc area ratio (p=0.033), vertical cup:disc ratio(p=0.005) and cup volume (p=0.003) , while there was a reduction in the rim area (p=0.020) as compared to baseline values (table1:Values given as mean ± standard deviation*Corresponding pairs: baseline and 3 mths, Wilcoxon Signed Ranks Test# Corresponding pairs: baseline and 6 mths, Wilcoxon Signed Ranks Test)
Pan Retinal Photocoagulation induces significant changes in the morphology of the Optic Nerve Head in patients with Diabetic Retinopathy as measured with HRT3. This is an important consideration in the diagnosis and progression of glaucoma based on optic disc cupping in patients who have previously undergone PRP.
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