March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
A Structure-Structure-Based Correlation Map Using SD-OCT Resembles Nerve Fiber Bundle Patterns in Glaucoma Subjects
Author Affiliations & Notes
  • Mona K. Garvin
    Center for the Prevention and Treatment of Visual Loss, Iowa City VA Health Care System, Iowa City, Iowa
    The Department of Electrical and Computer Engineering,
    The University of Iowa, Iowa City, Iowa
  • Michael D. Abràmoff
    Center for the Prevention and Treatment of Visual Loss, Iowa City VA Health Care System, Iowa City, Iowa
    The Department of Ophthalmology and Visual Sciences,
    The University of Iowa, Iowa City, Iowa
  • Kyungmoo Lee
    The Department of Electrical and Computer Engineering,
    The University of Iowa, Iowa City, Iowa
  • Meindert Niemeijer
    The Department of Electrical and Computer Engineering,
    The University of Iowa, Iowa City, Iowa
  • Milan Sonka
    The Department of Electrical and Computer Engineering,
    The Department of Ophthalmology and Visual Sciences,
    The University of Iowa, Iowa City, Iowa
  • Young H. Kwon
    The Department of Ophthalmology and Visual Sciences,
    The University of Iowa, Iowa City, Iowa
  • Footnotes
    Commercial Relationships  Mona K. Garvin, Patent application (P); Michael D. Abràmoff, Patent application (P); Kyungmoo Lee, None; Meindert Niemeijer, None; Milan Sonka, Patent application (P); Young H. Kwon, None
  • Footnotes
    Support  NIH grants R01 EY018853, R01 EY019112, and R01 EB004640; the Department of Veterans Affairs; Research to Prevent Blindness; the American Glaucoma Society; and the Hadley Glaucoma Research Fund
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 667. doi:
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      Mona K. Garvin, Michael D. Abràmoff, Kyungmoo Lee, Meindert Niemeijer, Milan Sonka, Young H. Kwon; A Structure-Structure-Based Correlation Map Using SD-OCT Resembles Nerve Fiber Bundle Patterns in Glaucoma Subjects. Invest. Ophthalmol. Vis. Sci. 2012;53(14):667.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To correlate the thicknesses of focal regions of the macular ganglion cell layer with those of the peripapillary nerve fiber layer using spectral-domain optical coherence tomography (SD-OCT) in two groups of subjects: those with glaucoma and those with glaucoma suspicion.

 
Methods:
 

Macula and optic-nerve-head SD-OCT volumes were obtained in 30 eyes of 30 subjects with open-angle glaucoma and in 27 eyes of 27 subjects with glaucoma suspicion. Using a custom automated computer algorithm, the thickness of 66 macular ganglion cell layer regions and the thickness of 12 peripapillary nerve fiber layer regions were measured from registered SD-OCT volumes. The mean thickness of each ganglion-cell-layer region was correlated to the mean thickness of each peripapillary-nerve-fiber-layer region across subjects in the two groups. Within each group, each ganglion-cell-layer region was labeled with the peripapillary-nerve-fiber-layer region with the highest correlation using a color-coded map.

 
Results:
 

The resulting color-coded map from the glaucoma group closely resembled the nerve-fiber-bundle pattern of retinal ganglion cells, but less of a resemblance was observed in the glaucoma-suspicion group (see Figure). The r2 value across all local macular-peripapillary correlations was significantly larger in the glaucoma group (0.56 ± 0.13 versus 0.37 ± 0.11; p < 0.001).

 
Conclusions:
 

A 2-D spatial nerve-fiber-bundle (NFB) map of the retina can be developed using structure-structure relationships from SD-OCT, with such a map more closely resembling expected nerve fiber bundles when constructed from subjects with definite glaucoma. The focal nature of the NFB damage in the analyzed glaucoma subjects was likely a critical factor in obtaining such a resemblance.  

 
Keywords: image processing • ganglion cells • nerve fiber layer 
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