March 2012
Volume 53, Issue 14
ARVO Annual Meeting Abstract  |   March 2012
Structure Versus Function In Central Subfield In Normal Eyes
Author Affiliations & Notes
  • Aiko Iwase
    Tajimi Iwase Eye Clinic, Tajimi, Japan
  • Sinsuke Konno
    Department of Ophthalmology, Univ of Tokyo School of Medicine, Tokyo, Japan
  • Makoto Araie
    Department of Ophthalmology, Univ of Tokyo School of Medicine, Tokyo, Japan
    Kanto Central Hospital, Tokyo, Japan
  • Footnotes
    Commercial Relationships  Aiko Iwase, Topcon (F), Zeiss (F); Sinsuke Konno, None; Makoto Araie, Topcon (F, R), Zeiss (F)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 694. doi:
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    • Get Citation

      Aiko Iwase, Sinsuke Konno, Makoto Araie; Structure Versus Function In Central Subfield In Normal Eyes. Invest. Ophthalmol. Vis. Sci. 2012;53(14):694.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To study structure-function relationship in macular area using spectral-domain optical coherence tomography (SD-OCT) and standard automated perimetry (SAP) in normal eyes.

Methods: : This cross-sectional study included132 right eyes of 132 normal subjects, 71 females/61 males; mean=54.5(SD=16.2)yrs. who underwent ophthalmic examinations and SAP with Humphrey Perimeter 24-2 SITA-Standard program (Carl Zeiss Meditec, Inc., Dublin, CA) to confirm absence of any ocular abnormalities and participated for the acquisition of the Japanese normative data base for Cirrus HD-OCT (Carl Zeiss ). Cirrus HD-OCT measurements using the Optic Disc Cube and Ganglion Cell Analysis (GCA, Version 6.0) protocols were done after pharmacological mydriasis 3 times each with several-second intervals and the best quality scans (signal strength ≥ 6, without misalignment, influences by involuntary blinking or saccade, or segmentation failure) were used. Correlation between the mean sensitivity (dB) of the all program test points and Log[mean circum-papillary retinal nerve fiber layer thickness (cpRNFLT)] and that between the sum of the sensitivity of the central subfield 6 test points and Log[mean cpRNFLT of the temporal 90° sector](Garway-Heath et al. Ophthalmology 2000;107:1809-15), Log[GCA-derived mean macular RNFLT] and Log[GCA-derived sum of mean macular ganglion cell layer (GCL) and inner plexiform layer (IPL) thickness (GCL+IPL)]were determined. The study was approved by the IRB of each institute.

Results: : Mean (SD) of refraction, mean sensitivity of the whole and central subfield 6 test points, mean cpRNFLT, mean temporal 90° cpRNFLT, macular RNFLT and (GCL+IPL) was -0.71(2.06) diopters, 30.2 (1.58) dB, 32.2 (1.52)dB, 94.0 (8.3)um, 71.7 (10.1) um, 34.5 (2.8) um and 82.6(4.9) um, respectively. Pearson's correlation coefficient between the structural measure and the corresponding visual field sensitivity was 0.06 (P>0.4) for mean cpRNFLT, 0.04 (P>0.5) for mean temporal 90° cpRNFLT, 0.285 (P=0.001) for macular RNFLT and 0.180 (P=0.039) for (GCL+IPL), respectively.

Conclusions: : Correlation of VF sensitivity and macular RNFLT or (GCL+IPL) was significant in normal eyes, while that of cpRNFLT was weak as previously reported, suggesting that the macular area is better suited for studying structure-function relationship in human eyes and may yield a more sensitive index of the earlier glaucomatous change than cpRNFLT.

Keywords: imaging/image analysis: clinical • visual fields • ganglion cells 

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