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Ayako Karakawa, Hitomi Saito, Makoto Araie, Aiko Iwase, Chihiro Mayama, Atsuo Tomidokoro; Macular Thickness Analysis By SD-OCT In Glaucoma Eyes With Hemi-retinal Damage. Invest. Ophthalmol. Vis. Sci. 2012;53(14):696.
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© ARVO (1962-2015); The Authors (2016-present)
To analyze macular thickness by spectral-domain optical coherence tomography (SD-OCT) in preperimetric glaucoma (PPG) and early glaucoma (EG) eyes with hemi-field defects, and age and refraction matched normal control eyes.
Twenty eight eyes of PPG with nerve fiber layer (NFL) defect or glaucomatous optic disc change in either hemi-retina or -disc, 56 eyes of EG with hemi-field defects (mean deviation> -6dB), and 28 and 56 age (±1yr) - and refraction (±1 D) - matched normal eyes were enrolled and one eye from a subject was used. SD-OCT (3D OCT-1000 Ver. 3.20, Topcon, Japan) was used to measure thickness of the NFL, the ganglion cell layer plus (GCP, ganglion cell layer + inner plexiform layer), and the ganglion cell layer complex (GCC, GCP+NFL) in the macular area and the circumpapillary NFL (cpNFL). Macular thickness parameters of the normal and affected abnormal hemi-retina in PPG and EG eyes were compared to that of the macular parameters of the corresponding hemi-retina in normal control eyes. The study was approved by the Institutional review board of each.
All macular thickness parameters and cpNFL thickness of the affected hemi-retina in both PPG (NFL; GCP;GCC: p <0.001, cpNFL: P=0.025) and EG (NFL; GCP; GCC; cpNFL: p<0.001 ) were thinner than that of the corresponding parameters in normal eyes. NFL and GCC thickness of the apparently normal hemi-retina or -disc in PPG eyes (NFL: p=0.012, GCC: p=0.028 ) was thinner than that of the corresponding parameters in normal eyes, while no significant difference was observed in other parameters. All macular thickness parameters and cpNFL of the unaffected normal hemi-retina in EG eyes (NFL: p=0.001, GCP; GCC; cpNFL: p <0.001) were thinner than that of the corresponding parameters in normal eyes.
Macular thickness parameters of PPG and EG eyes were significantly thinner compared to those of control normal eyes not only in the affected abnormal hemi-field or -retina but also in the unaffected normal hemi-retina or -disc, indicating the preceding structural change in the macular region prior to visual field loss, and/or visible glaucomatous change in the retinal nerve fiber layer or disc appearance. Selective measurement of the macular area by SD-OCT may be more sensitive in detecting the earliest glaucomatous changes.
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