Abstract
Purpose: :
The purpose of this study was to determine the structure most significantly correlated with visual acuity in open-angle glaucoma (OAG) using Spectral Domain Optical Coherence Tomography (SD-OCT).
Methods: :
One sixty-five eyes of 42 patients with OAG were enrolled in Glaucoma Department of S.M. Goretti Hospital (Latina). Participants underwent SD-OCT 'RNFL and Thickness Map' (SD-OCT with eye tracking and averaging of 16 images at the same location to reduce speckle noise; Spectralis HRA+OCT; Heidelberg Engineering, Heidelberg, Germany), and the best corrected visual acuity (BCVA) was obtained during the same visit. The relationship between BCVA and OCT parameters was evaluated using Spearman’s correlation test and regression analysis. Multivariate regression analysis was performed using the BCVA value as a dependent variable. After defining eyes with a BCVA < 0.6 and a logistic regression analysis was performed with the areas under the receiver operating characteristic (AUROC) curve for variable OCT parameters.
Results: :
RNFL parameters were significantly correlated with BCVA in the severe glaucoma group while the correlation between BCVA and RNFL parameters was limited in the early to moderate glaucoma group. Regard RNFL parameters, the coefficient of correlation was the highest for the lower temporal (TL) sector followed by upper temporal (TU) sector that corresponding to the papillomacular bundle area in the severe glaucoma group. Multivariate analysis revealed that cup disc area ratio and papillomacular bundle RNFL thickness were significantly associated with visual acuity. Logistic regression analysis showed that AUROC of the average RNFL was 0.978 (95%), and that of average Thickness Map was 0.921 (95%).
Conclusions: :
Analysis of the different regions of RNFL thickness showed that RNFL thickness corresponding to the papillomacular bundle area had the highest correlation to the visual acuity. Multiple SD-OCT parameters were significantly correlated with visual acuity in glaucoma patients and these correlations were stronger in patients with more advanced disease.
Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • nerve fiber layer • visual acuity