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Florian Alten, Christoph R. Clemens, Carolin Milojcic, Nicole Eter; Reticular Drusen Associated With Pigment Epithelium Detachment Due To Age-related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2011;52(14):102.
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To characterize reticular drusen (RD) in patients with pigment epithelium detachment (PED) secondary to age-related macular degeneration (AMD) using confocal scanning laser ophthalmoscopy (SLO) and spectral-domain optical coherence tomography (SD-OCT) imaging.
107 patients with PED secondary to AMD in one or both eyes (77 females, 30 males; age 75.3 ± 8.4 years) were included. Fluorescence angiography and SD-OCT (Heidelberg Retina Angiograph/Spectralis, Heidelberg Engineering, Germany) was performed for diagnosis. Near-infrared reflectance (NIR, = 830 nm) images were recorded and evaluated for prevalence of RD by two independent readers. In case of discrepancy, a third grader was asked to arbitrate.
RD were present in 44 of 107 (41.1%) patients in at least one eye (159 PED in total). 38 patients showed RD in both eyes (86.4%). 30 patients with RD in at least one eye were older than 75 years (68.2%). 28 eyes had drusenoid PED (17.6%), 131 eyes had exsudative PED (82,4%). NIR images showed no difference in RD prevalence. In 61 of 214 eyes (28.5%) NIR image quality was insufficient for grading.
RD represent a common phenotypic hallmark in eyes with PED secondary to AMD. Nevertheless, RD are less common in patients with PED than with geographic atrophy secondary to AMD. Good image quality is crucial for RD grading. The morphologic substrate of RD and a possible pathophysiologic role in AMD is yet to be demonstrated.
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