Clinical Effects Of Anti-vegf On The Wet-amd According To The Cnv Caliber In Icga Images

Abstract

Purpose: : To investigate the effects of anti-VEGF on the patients with the wet-AMD according to the CNV caliber in ICGA images.

Methods: : The medical records of thirty three eyes were reviewed to collect best corrected visual acuity (logMAR, BCVA), SD-OCT, fundus photograph, FA and ICGA images at the baseline, 6 months and 12 months after the injection of anti-VEGF. We calculated the maximal caliber of CNV in ICGA using EyeVAN program (ver. 1.3, College of Engineering Fundus Photography Reading Center, University of Wisconsin-Madison, USA) after the identification of CNV lesion in the fundus photograph and FA.

Results: : CNV caliber could be calculated in 54.6 % (18/33 eyes) by EyeVAN. Mean CNV caliber, mean central subfield macular thickness and mean BCVA were 47.87 ± 9.41 um, 353.4 ± 118.3 um and 0.78 ± 0.60 at the baseline. 6 months and 12 months after anti-VEGF injection, CSMT was significantly reduced into 255.7 ± 53.9 and 264.4 ± 86.2 um (p<0.05) and mean VA was likely to improve to 0.58 ± 0.51 and 0.55 ± 0.63. The larger CNV caliber was, the thicker CSMT was at 6 and 12 months of follow-up time, statistically. (p₆=0.049, r₆=0.469; p₁₂=0.035, r₁₂=0.565; Spearman correlation) The CNV caliber had no relationship with total CNV lesion, VA and number of anti-VEGF injection.

Conclusions: : We could measure the CNV caliber and find that the larger CNV caliber was, the lower effect of anti-VEGF was on the anatomical recovery in Wet AMD.

Keywords: choroid: neovascularization • age-related macular degeneration • imaging/image analysis: clinical