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Ik Soo Byon, Sang Jun Lee, Na Mi Kim, Hyun Jun Park, Hee Young Choi, Ji Eun Lee, Boo Sup Oum; Clinical Effects Of Anti-vegf On The Wet-amd According To The Cnv Caliber In Icga Images. Invest. Ophthalmol. Vis. Sci. 2011;52(14):137.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the effects of anti-VEGF on the patients with the wet-AMD according to the CNV caliber in ICGA images.
The medical records of thirty three eyes were reviewed to collect best corrected visual acuity (logMAR, BCVA), SD-OCT, fundus photograph, FA and ICGA images at the baseline, 6 months and 12 months after the injection of anti-VEGF. We calculated the maximal caliber of CNV in ICGA using EyeVAN program (ver. 1.3, College of Engineering Fundus Photography Reading Center, University of Wisconsin-Madison, USA) after the identification of CNV lesion in the fundus photograph and FA.
CNV caliber could be calculated in 54.6 % (18/33 eyes) by EyeVAN. Mean CNV caliber, mean central subfield macular thickness and mean BCVA were 47.87 ± 9.41 um, 353.4 ± 118.3 um and 0.78 ± 0.60 at the baseline. 6 months and 12 months after anti-VEGF injection, CSMT was significantly reduced into 255.7 ± 53.9 and 264.4 ± 86.2 um (p<0.05) and mean VA was likely to improve to 0.58 ± 0.51 and 0.55 ± 0.63. The larger CNV caliber was, the thicker CSMT was at 6 and 12 months of follow-up time, statistically. (p6=0.049, r6=0.469; p12=0.035, r12=0.565; Spearman correlation) The CNV caliber had no relationship with total CNV lesion, VA and number of anti-VEGF injection.
We could measure the CNV caliber and find that the larger CNV caliber was, the lower effect of anti-VEGF was on the anatomical recovery in Wet AMD.
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