April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
Oct-SD Versus Fluorescein Angiography For Evaluation Of Exudative Features In Wet Age-related Macular Degeneration
Author Affiliations & Notes
  • Claire Scemama Timsit
    94, CHIC Creteil, Creteil, France
  • Giuseppe Querques
    94, CHIC Creteil, Creteil, France
  • Celine Terrada
    Ophthalmology, CHI Creteil, Paris, France
  • Valerie Letien
    94, CHIC Creteil, Creteil, France
  • Nathalie Massamba
    Ophthal-Hosp Intercommunal, Centre Hosp Intercommunal Creteil, Creteil, France
  • Gerard Mimoun
    94, CHIC Creteil, Creteil, France
  • Eric H. Souied
    Retina Creteil, University Paris Est Creteil, Creteil, France
  • Footnotes
    Commercial Relationships  Claire Scemama Timsit, None; Giuseppe Querques, None; Celine Terrada, None; Valerie Letien, None; Nathalie Massamba, None; Gerard Mimoun, None; Eric H. Souied, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 141. doi:
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      Claire Scemama Timsit, Giuseppe Querques, Celine Terrada, Valerie Letien, Nathalie Massamba, Gerard Mimoun, Eric H. Souied; Oct-SD Versus Fluorescein Angiography For Evaluation Of Exudative Features In Wet Age-related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2011;52(14):141.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : Imaging for evaluation of exudative signs in wet age-related macular degeneration (AMD) can be performed either on optical coherence tomography (OCT), fluorescein angiography (FA), or both. This study compares and analyzes OCT versus with FA exudative features in 117 eyes of 106 patients, during ranibizumab therapy in exudative AMD. Our purpose was to investigate whether examination with Spectral Domain OCT (SD-OCT) alone is sufficient to ascertain the need of re-treatment with ranibizumab in exudative AMD or if FA is needed.

Methods: : Retrospective, comparative study of 106 patients (117 eyes) with exudative AMD including 50 occult choroidal neovascularisation (type 1), 22 polypoidal choroidal vasculopathy (PCV), 23 chorioretinal anastomosis (CRA) and 22 classic choroidal neovascularisation (type 2). All cases were selected after the 6 first months of treatment by ranibizumab. SD-OCT and FA (Spectralis HRA-OCT Heidelberg Engineering, Heidelberg, Germany) were analyzed retrospectively and separately by 2 different experts (double reading). SD-OCT criteria for judgment of persistence of activity of the lesion were presence of any fluid, macular edema. FA criterion for judgment of persistence of activity of the lesion was leakage on late phases. The results of both imaging were compared in all sub-groups of wet AMD.

Results: : The mean age was 76,6 years; 29.8% were male, 70,2% female. In total among 117 eyes there was a 16,2 % conflict (19/117) between OCT and AF features. The divergence between FA and OCT was observed in 16% (8/50) of type 1, in 4.5 % (1/22) of CRA, in 4.3% (1/23) of PVC and in 50 % (11/22) of type 2 cases.

Conclusions: : Several studies demonstrated advantage of OCT-SD in detecting minor structural changes (cystoid macular edema, subretinal fluid, retinal pigment epithelium detachment increase, photoreceptor atrophy…). Our study shows the complementarities of these two imaging approaches. We suggest that FA should be performed on a regular basis in the follow-up of exudative AMD patients treated by anti-VEGF, particularly for type 2 CNV.

Keywords: age-related macular degeneration • retina • imaging/image analysis: clinical 

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