April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Prognostic Value Of SDOCT And Angiography For Visual Acuity Outcome After Ranibizumab In Patients With Neovascular AMD
Author Affiliations & Notes
  • Tina Ristau
    Cologne Image Reading Center, Center of Ophthalmology, University of Cologne, Cologne, Germany
  • Steffen Hillebrand
    Cologne Image Reading Center, Center of Ophthalmology, University of Cologne, Cologne, Germany
  • Dzenita Smailhodzic
    Department of Ophthalmology, UMCN St Radboud, Nijmegen, The Netherlands
  • Jared Updike
    Doheny Image Reading Center, Doheny Eye Institute - USC, Los Angeles, California
  • Alexander C. Walsh
    Doheny Image Reading Center, Doheny Eye Institute - USC, Los Angeles, California
  • Bernd Kirchhof
    Cologne Image Reading Center, Center of Ophthalmology, University of Cologne, Cologne, Germany
  • Srinivas R. Sadda
    Doheny Image Reading Center, Doheny Eye Institute - USC, Los Angeles, California
  • Sandra Liakopoulos
    Cologne Image Reading Center, Center of Ophthalmology, University of Cologne, Cologne, Germany
  • Footnotes
    Commercial Relationships  Tina Ristau, Novartis (R); Steffen Hillebrand, None; Dzenita Smailhodzic, None; Jared Updike, Topcon Medical Systems (P); Alexander C. Walsh, Heidelberg Engineering (C), Topcon Medical Systems (P); Bernd Kirchhof, None; Srinivas R. Sadda, Carl Zeiss Meditec, Opovue Inc. (F), Heidelberg Engineering (C), Topcon Medical Systems (P, R); Sandra Liakopoulos, Novartis (R)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 144. doi:
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      Tina Ristau, Steffen Hillebrand, Dzenita Smailhodzic, Jared Updike, Alexander C. Walsh, Bernd Kirchhof, Srinivas R. Sadda, Sandra Liakopoulos; Prognostic Value Of SDOCT And Angiography For Visual Acuity Outcome After Ranibizumab In Patients With Neovascular AMD. Invest. Ophthalmol. Vis. Sci. 2011;52(14):144.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate whether spectral domain OCT (SDOCT) and fluorescein angiography (FA) findings are predictive of visual acuity (VA) after Ranibizumab therapy for neovascular AMD.

Methods: : Best corrected VA of 72 previously untreated eyes with NVAMD were retrospectively collected at baseline, after 3 injections and at 12 months follow-up. CNV lesion components on FA were qualitatively and quantitatively analyzed using reading center software. SDOCT images were qualitatively (n=72) and quantitatively (n=62) evaluated using the manual grading software 3D OCTOR. Thickness was calculated for the spaces retina, photoreceptor layer, subretinal fluid, subretinal tissue and pigment epithelial detachment (PED). VA as well as change in VA from baseline were correlated with all parameters.

Results: : Lower VA at baseline significantly correlated with lower VA (R=0.7 after 3 injections / R=0.6 at 12 months) as well as greater increase in VA (R=0.3 after 3 injections /R=0.5 at 12 months).Eyes with RAP on FA showed a greater increase in VA after 3 injections than eyes with occult CNV without RAP. Greater area of the total CNV lesion correlated with lower VA after 3 injections (R=0.3) and at 12 months (R=0.5). Greater area of the classic CNV component correlated with lower VA after 3 injections (R=0.3) and greater area of the occult CNV component correlated with lower VA after 12 months (R=0.5).On SDOCT, eyes with cystoid spaces had lower VA after 3 injections than eyes without cystoid spaces. Greater retinal thickness correlated with greater VA increase after 3 injections (R=0.3). Greater thickness of subretinal tissue and a thinner photoreceptor layer correlated with lower VA after 3 injections (R=0.4; R=-0.4). Greater thickness of PED and a thinner photoreceptor layer correlated with lower VA at 12 months (R=0.4; R=-0.4).

Conclusions: : Several parameters on FA and SDOCT images showed prognostic value for VA outcome after Ranibizumab in NVAMD. A larger, prospective dataset will be crucial for defining the relative importance of these parameters.

Keywords: age-related macular degeneration • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • visual acuity 
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