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Gabor G. Deak, Matthias Bolz, Mario Bittner, Jan Lammer, Erich Gotzinger, Michael Pircher, Christoph K. Hitzenberger, Ursula Schmidt-Erfurth; Polarisation Sensitive Optical Coherence Tomography Based Detection Of Microexudates In Age-related Macular Degeneration: New Insights In Patho-morphologic Details. Invest. Ophthalmol. Vis. Sci. 2011;52(14):153.
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To evaluate spatial distribution and depolarizing characteristics of retinal microexudates (ME) in age-related macular degeneration (AMD) using spectral domain optical coherence tomography (SD-OCT) and polarization sensitive optical coherence tomography (PS-OCT).
In this cross-sectional study, 20 eyes with exudative AMD were examined using color fundus photography (CFP), SD-OCT and PS-OCT. Images were reviewed by a masked investigator regarding the intraretinal localization, distribution and depolarizing status of retinal microexudates.
In all eyes, mircoexudates detected by SD-OCT and PS-OCT distributed throughout all retinal layers, but most prominently at the border of the outer nuclear layer (ONL) and the inner segment/outer segment layer (IS/OS). With color fundus photography MEs were undetectable, however conglomerated MEs forming clinically significant hard exudates were detectable. On PS-OCT not all microexudates showed depolarizing characteristics.
This study showed that microexudates in AMD could be detected by SD-OCT and PS-OCT but not on color fundus photography. Although on SD-OCT all mircoexudates looked similar PS-OCT showed that they differ in their depolarizing quality, implying that ME form a heterogeneous group. Further investigations are necessary to clarify the dynamics of ME distribution over time. PS-OCT is a valuable device to examine and quantify microexudates.
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