April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Vision-determining Structure In Open Angle Glaucoma Patient Using Spectral Domain Optical Coherence Tomography
Author Affiliations & Notes
  • Ji Hyun Kim
    Ophthalmology, Siloam eye hospital, Seoul, Republic of Korea
  • SeungSoo Rho
    Ophthalmology, Yonsei University College of medicine,, Seoul, Republic of Korea
  • Na Rae Kim
    Ophthalmology, Yonsei University College of medicine,, Seoul, Republic of Korea
  • Sa Min Hong
    Ophthalmology, Yonsei University College of medicine,, Seoul, Republic of Korea
  • Eun Suk Lee
    Ophthalmology, Yonsei University College of medicine,, Seoul, Republic of Korea
  • Gong Je Seong
    Ophthalmology, Yonsei University College of medicine,, Seoul, Republic of Korea
  • Chan Yun Kim
    Ophthalmology, Yonsei University College of medicine,, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships  Ji Hyun Kim, None; SeungSoo Rho, None; Na Rae Kim, None; Sa Min Hong, None; Eun Suk Lee, None; Gong Je Seong, None; Chan Yun Kim, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 164. doi:
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      Ji Hyun Kim, SeungSoo Rho, Na Rae Kim, Sa Min Hong, Eun Suk Lee, Gong Je Seong, Chan Yun Kim; Vision-determining Structure In Open Angle Glaucoma Patient Using Spectral Domain Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2011;52(14):164.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To determine the structure most significantly correlated with visual acuity in open-angle glaucoma (OAG) using Spectral Domain Optical Coherence Tomography (SD-OCT).

Methods: : One hundred seventy-eight eyes of 178 patients with OAG were consecutively enrolled from January 2010 to June 2010. Participants underwent RTVue OCT (ONH scan and GCC scan, Optovue Inc, Fremont, CA), and the best corrected visual acuity (BCVA) was obtained during the same visit. The relationship between BCVA and OCT parameters was evaluated using Spearman’s correlation test and regression analysis. Multivariate regression analysis was performed using the BCVA value as a dependent variable. After defining eyes with a BCVA <0.7 as the group having decreased BCVA, a logistic regression analysis was performed with the areas under the receiver operating characteristic (AUROC) curve for variable OCT parameters.

Results: : Although the correlation between BCVA and RNFL parameters was limited in the early to moderate glaucoma group, most RNFL parameters were significantly correlated with BCVA in the severe glaucoma group. Of all RNFL parameters, the coefficient of correlation was the highest for the lower temporal (TL) sector, followed by upper temporal (TU) sector, corresponding to the papillomacular bundle area in the severe glaucoma group. Multivariate analysis revealed that papillomacular bundle RNFL thickness and cup to disc area ratio was significantly associated with visual acuity. Logistic regression analysis showed that AUROC of the average RNFL was 0.931 (95% CI: 0.887-0.975), and that of average GCC was 0.875 (95% CI: 0.779-0.972).

Conclusions: : Multiple SD-OCT parameters were significantly correlated with visual acuity in glaucoma patients, and such correlations were stronger in patients with more advanced disease. Analysis of the different regions of RNFL thickness showed that RNFL thickness corresponding to the papillomacular bundle area had the highest correlation to the visual acuity.

Keywords: visual acuity • imaging/image analysis: clinical • ganglion cells 
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