Purchase this article with an account.
Kristen K. Buono, Mauro T. Leite, Christopher Bowd, Robert N. Weinreb, Felipe A. Medeiros, Christopher A. Girkin, Jeffrey M. Liebmann, Pamela A. Sample, Linda M. Zangwill; African Descent and Glaucoma Evaluation Study (ADAGES): Effect of Age, Image Quality and Race on Spectral Domain Optical Coherence Tomography (SDOCT) Retinal Nerve Fiber Layer (RNFL) Thickness Measurements. Invest. Ophthalmol. Vis. Sci. 2011;52(14):167.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To evaluate the effects of age, image quality and race on RNFL thickness measurements obtained with SDOCT in healthy participants of African descent (AD) and European descent (ED).
One hundred eighty one eyes (AD 59 eyes, ED 122 eyes) from 97 healthy participants from the Diagnostic Innovations in Glaucoma Study (DIGS) and the ADAGES had good quality Spectralis SDOCT (Heidelberg Engineering) images. 195 eyes of 98 participants had Cirrus HD-OCT (Carl Zeiss Meditec) images. Univariable and multivariable linear mixed models were built to evaluate the effects of age, scan quality score and race on global and sectoral RNFL thickness measurements.
Overall, there was an inverse association with age and Spectralis RNFL thickness measurements for the global (0.15∝m/yr; P=0.006), superotemporal (0.23∝m/yr; P=0.012), inferotemporal (0.28∝m/yr; P=0.009) and inferonasal (0.33∝m/yr; P=0.01) sectors. For the Cirrus, RNFL thickness decrease with age was found for the global (0.21∝m/yr; P<0.001), the superior (0.29∝m/yr; P<0.001) and the inferior (0.44∝m/yr; P<0.001) sectors. For the Spectralis and Cirrus RNFL thickness was positively correlated with scan quality. After adjusting for image quality, age still had a significant influence on Spectralis global, superotemporal, inferotemporal and inferonasal RNFL measurements (all P<0.02) and Cirrus global, superior and inferior RNFL measurements (all P<0.02). In general, the decline in RNFL thickness with increasing age tended to be faster in AD compared to ED eyes, but these differences did not reach statistical significance (all sectors P>0.07).
There was a significant reduction in the RNFL measurements with increasing age in both AD and ED, particularly for the inferior quadrant, which is often the location of glaucomatous deterioration. Age-associated thinning should be considered when following RNFL measurements over time with these instruments.
Clinical Trial: :
This PDF is available to Subscribers Only