April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
African Descent and Glaucoma Evaluation Study (ADAGES): Effect of Age, Image Quality and Race on Spectral Domain Optical Coherence Tomography (SDOCT) Retinal Nerve Fiber Layer (RNFL) Thickness Measurements
Author Affiliations & Notes
  • Kristen K. Buono
    Ophthalmology, Hamilton Glaucoma Center, University of California San Diego, California
  • Mauro T. Leite
    Ophthalmology, Hamilton Glaucoma Center, University of California San Diego, California
    Ophthalmology, Federal University of São Paulo, São Paulo, Brazil
  • Christopher Bowd
    Ophthalmology, Hamilton Glaucoma Center, University of California San Diego, California
  • Robert N. Weinreb
    Ophthalmology, Hamilton Glaucoma Center, University of California San Diego, California
  • Felipe A. Medeiros
    Ophthalmology, Hamilton Glaucoma Center, University of California San Diego, California
    Ophthalmology, University of São Paulo, São Paulo, Brazil
  • Christopher A. Girkin
    School of Medicine, University of Alabama at Birmingham, Alabama
  • Jeffrey M. Liebmann
    School of Medicine, New York University, New York
    New York Eye and Ear Infirmary, New York, New York
  • Pamela A. Sample
    Ophthalmology, Hamilton Glaucoma Center, University of California San Diego, California
  • Linda M. Zangwill
    Ophthalmology, Hamilton Glaucoma Center, University of California San Diego, California
  • Footnotes
    Commercial Relationships  Kristen K. Buono, None; Mauro T. Leite, None; Christopher Bowd, Pfizer, Inc (F); Robert N. Weinreb, Alcon Laboratories Inc (C), Allergan Inc (C), Carl Zeiss Meditec Inc (F, C), Heidelberg Engineering GmbH (F), Merck Inc (C), Novartis Inc (F), Optovue Inc (F, C), Pfizer Inc (C), Topcon Medical Systems Inc (F); Felipe A. Medeiros, Alcon Laboratories Inc (F, C, R), Allergan Inc (C, R), Carl Zeiss Meditec Inc (F, R), Merck Inc (F), Pfizer Inc (F, C, R), Reichert Inc (R); Christopher A. Girkin, Alcon Laboratories Inc (C), Allergan Inc (C), Carl Zeiss Meditec Inc (R), Heidelberg Engineering GmbH (R), Merck Inc (R), Optive Inc (R), Pfizer Inc (C), Topcon Medical Systems Inc (R); Jeffrey M. Liebmann, Alcon Laboratories Inc (C), Allergan Inc (C), Carl Zeiss Meditec Inc (F), Dyopsis Corp (F, C), Heidelberg Engineering GmbH (F), Optovue Inc (F, C), Pfizer Inc (C), Topcon Medical Systems Inc (F, C); Pamela A. Sample, Carl Zeiss Meditec Inc (F), Haag-Streit Inc (F); Linda M. Zangwill, Carl Zeiss Meditec Inc (F), Heidelberg Engineering GmbH (F, R), Optovue Inc (F), Topcon Medical Systems Inc (F)
  • Footnotes
    Support  NEI grants U10EY14267, EY019869, and EY08208, EY11008, and EY13959 and Eyesight Foundation of Alabama; Alcon Laboratories Inc.; Allergan Inc.; Pfizer Inc.; Merck Inc.; Santen Inc.; and the Corrine Gra
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 167. doi:
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      Kristen K. Buono, Mauro T. Leite, Christopher Bowd, Robert N. Weinreb, Felipe A. Medeiros, Christopher A. Girkin, Jeffrey M. Liebmann, Pamela A. Sample, Linda M. Zangwill; African Descent and Glaucoma Evaluation Study (ADAGES): Effect of Age, Image Quality and Race on Spectral Domain Optical Coherence Tomography (SDOCT) Retinal Nerve Fiber Layer (RNFL) Thickness Measurements. Invest. Ophthalmol. Vis. Sci. 2011;52(14):167.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the effects of age, image quality and race on RNFL thickness measurements obtained with SDOCT in healthy participants of African descent (AD) and European descent (ED).

Methods: : One hundred eighty one eyes (AD 59 eyes, ED 122 eyes) from 97 healthy participants from the Diagnostic Innovations in Glaucoma Study (DIGS) and the ADAGES had good quality Spectralis SDOCT (Heidelberg Engineering) images. 195 eyes of 98 participants had Cirrus HD-OCT (Carl Zeiss Meditec) images. Univariable and multivariable linear mixed models were built to evaluate the effects of age, scan quality score and race on global and sectoral RNFL thickness measurements.

Results: : Overall, there was an inverse association with age and Spectralis RNFL thickness measurements for the global (0.15∝m/yr; P=0.006), superotemporal (0.23∝m/yr; P=0.012), inferotemporal (0.28∝m/yr; P=0.009) and inferonasal (0.33∝m/yr; P=0.01) sectors. For the Cirrus, RNFL thickness decrease with age was found for the global (0.21∝m/yr; P<0.001), the superior (0.29∝m/yr; P<0.001) and the inferior (0.44∝m/yr; P<0.001) sectors. For the Spectralis and Cirrus RNFL thickness was positively correlated with scan quality. After adjusting for image quality, age still had a significant influence on Spectralis global, superotemporal, inferotemporal and inferonasal RNFL measurements (all P<0.02) and Cirrus global, superior and inferior RNFL measurements (all P<0.02). In general, the decline in RNFL thickness with increasing age tended to be faster in AD compared to ED eyes, but these differences did not reach statistical significance (all sectors P>0.07).

Conclusions: : There was a significant reduction in the RNFL measurements with increasing age in both AD and ED, particularly for the inferior quadrant, which is often the location of glaucomatous deterioration. Age-associated thinning should be considered when following RNFL measurements over time with these instruments.

Clinical Trial: : http://www.clinicaltrials.gov NCT00000125

Keywords: imaging/image analysis: clinical 
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