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Jonathan Erickson, Maria Cecilia Reyes, Namita Bhardwaj, Wei Shi, Mitra Sehi, David S. Greenfield; The Effect Of Cataract Grade And Location On Quality Of Ocular Imaging Scans. Invest. Ophthalmol. Vis. Sci. 2011;52(14):168.
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To determine the effect of cataract grade and location on quality of imaging scans obtained using confocal scanning laser ophthalmoscopy (CSLO), scanning laser polarimetry (SLPVCC and ECC), time-domain OCT (TDOCT), and fourier-domain OCT (FDOCT).
Phakic eyes of normal, glaucoma suspect, and glaucomatous patients meeting eligibility criteria were prospectively studied. One eye per subject was enrolled. Subjects underwent ophthalmologic examination and cataract grading was performed according to the Lens Opacities Classification System (LOCS III). Ocular imaging scans were performed at a single session by the same operators. Image quality measures consisted of pixel standard deviation (CSLO), typical scan score and Q score (SLPVCC and ECC), signal strength (TDOCT), and SSI (FDOCT). Mean quality measures were calculated from two imaging exams performed at the same session. Pearson correlation coefficients were calculated to examine the association between nuclear, cortical, and posterior subcapsular scores and imaging quality measures.
Thirty-five eyes of 35 patients (3 normal, 24 glaucoma suspect, 8 glaucoma) were enrolled. The mean age was 65.3 + 8.7 years. Mean logMAR visual acuity was -0.0163 + 0.069 (20/20). Average LOCS III grade for each cataract location were; nuclear 2.44, cortical 0.78, and posterior subcapsular 0.39. There was a significant correlation between higher nuclear opalescence and color scores and greater CSLO standard deviation values (r =0.62, p <0.001). Q score, TSS, signal strength, and SSI did not correlate with nuclear, cortical, or posterior subcapsular grades.
Image quality scores using SLPVCC and ECC, TDOCT, and FDOCT are unaffected by early cataract. Nuclear cataract adversely affects CSLO standard deviation.
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