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David S. Chen, Carol Y. Cheung, Tien Y. Wong, Renyi Wu, Yingfeng Zheng, Seang-Mei Saw, Christopher K. Leung, Tin Aung; Determinants of Optic Nerve Measurements Using High Definition Optical Coherence Tomography in Normal Subjects: the Singapore Chinese Eye Study. Invest. Ophthalmol. Vis. Sci. 2011;52(14):172.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the factors influencing measurements of retinal nerve fiber layer (RNFL) thickness and optic nerve head (ONH) parameters with High-Definition Optical Coherence Tomography (HD-OCT) in healthy Chinese adults from the general population.
Adults aged 40 to 80 years were consecutively recruited from the population-based Singapore Chinese Eye Study from Feb 2009 to July 2010. Cirrus HD-OCT (Carl Zeiss Meditec Inc, Dublin, CA, software version 5.0) with the Optic Disk Cube 200x200 scan protocol was used to measure RNFL and ONH parameters. A total of 508 eyes from 508 healthy Chinese subjects with normal visual field test and intraocular pressure not higher than 21mmHg were analyzed. Linear regression analyses were performed to examine the associations between RNFL and ONH parameters with age, gender, axial length, spherical equivalent, anterior chamber depth, central corneal thickness, disc area, visual field, and signal strength.
In this population, mean RNFL thickness was 98.0µm (SD=9.1) and mean rim area 1.30mm2 (SD=0.23). In multiple linear regression analyses, average RNFL thickness was associated with age (β=-0.16, 95% CI: -0.28, -0.037, P=0.011), axial length (β=-0.94, 95% CI: -1.71, -0.17, P=0.016), disc area ( β=6.07, 95% CI: 3.98, 8.16, P<0.001) and HD-OCT signal strength (β=1.16, 95% CI: 0.37, 1.94, P=0.004). Rim area was associated with age (β=-0.003, 95% CI: -0.006, -0.00003, P=0.031), anterior chamber depth (β=-0.072, 95% CI: -0.14, -0.009, P=0.025) and disc area ((β=0.26, 95% CI: 0.21, 0.31, P<0.001). Both RNFL thickness and rim area were not associated with central corneal thickness.
Optic nerve measurements with HD-OCT vary with age, axial length, disc area, signal strength, anterior chamber depth, in healthy Chinese subjects. These factors should be taken into account when interpreting HD-OCT scans in a clinical setting.
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