Purchase this article with an account.
Jacek Kotowski, Lindsey S. Folio, Gadi Wollstein, Larry Kagemann, Hiroshi Ishikawa, Yun Ling, Richard A. Bilonick, James G. Fujimoto, Joel S. Schuman; Glaucoma Discrimination of Segmented Cirrus Spectral Domain Optical Coherence Tomography (SD-OCT) Macular Scans. Invest. Ophthalmol. Vis. Sci. 2011;52(14):182.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
To evaluate the glaucoma diagnostic ability of Cirrus SD-OCT macular segmentation.
163 subjects (51 healthy, 49 glaucoma suspects and 63 glaucomatous eyes) were imaged with SD-OCT (Cirrus HD-OCT; Carl Zeiss Meditec, Dublin, CA; Macular and ONH cube protocols). Macular scans were segmented using the manufacturer’s pre-release software into nerve fiber layer (NFL), ganglion cell + inner plexiform layers (inner retinal complex - IRC), outer retinal complex (ORC) and total retina (TR). Age adjusted areas under the receiver operator characteristic curves (AUC) were calculated for overall and sectoral macular layer thickness and circumpapillary retinal NFL (cpRNFL). Glaucoma and glaucoma suspect eyes were grouped together as non-healthy.
The median visual field mean deviation (MD) for healthy and non-healthy eyes was -0.18 (interquartile range - IQR: -3.14 to 0.78) and -0. 95dB (IQR: -0.92 to 0.71), respectively (p<0.001, Wilcoxon test). IRC+NFL had the highest AUC among global macular layers (0.816, 95% CI: 0.748-0.884) followed by IRC (0.808; 0.737-0.879), TR (0.774; 0.697-0.851), NFL (0.766; 0.689-0.843), ORC (0.709; 0.617-0.800). Inferior IRC had the highest AUC (0.827; 0.759-0.894) among the sectoral macular parameters. AUC of cpRNFL was 0.818 (95% CI: 0.753-0.883). No statistically significant difference was detected between the AUCs of global macular parameters and cpRNFL, except for ORC.
Cirrus SD-OCT inner retinal macular thickness measurements showed glaucoma diagnostic ability similar to cpRNFL. Macular thickness measurements may be a complementary or an alternative measurement to RNFL thickness assessment in the clinical evaluation of glaucoma.
This PDF is available to Subscribers Only