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Jin Wook Jeoung, Tae-Woo Kim, Seok Hwan Kim, Ki Ho Park, Dong Myung Kim; Comparison of Spectralis OCT and Stratus OCT on the Ability to Detect Localized Retinal Nerve Fiber Layer Defects in Patients with Open-Angle Glaucoma. Invest. Ophthalmol. Vis. Sci. 2011;52(14):201.
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To evaluate and compare the diagnostic abilities of the Spectralis and Stratus optical coherence tomography (OCT) with its internal normative database to discriminate between healthy eyes and eyes with a localized retinal nerve fiber layer (RNFL) defects.
This study included 84 eyes of 84 subjects with localized RNFL defects and 116 healthy eyes of 116 control subjects. Areas under the receiver operating characteristic curves (AUROCs) were calculated and compared. Based on the internal normative database from each device, the sensitivity and specificity for detecting localized RNFL defects were calculated.
The best parameter from Spectralis OCT had a higher AUROC (inferotemporal sector, AUROC=0.925) than that of Stratus OCT (7 o’clock sector, AUROC=0.901); however, it was not statistically significant (P = 0.065). The sensitivity of the Spectralis OCT parameters ranged from 49.0% to 92.9% and that of the Stratus OCT parameters ranged from 29.6% to 70.4%, with the criterion of abnormal at the 5% level. Based on the normative database, the highest sensitivity was obtained with the TSNIT thickness graph that was abnormal at the < 5% level, which had a specificity of 86.2% for each device.
There were no significant differences between the AUROCs for Spectralis and Stratus OCT. After comparison with their normative databases, the sensitivity of Spectralis OCT was generally higher than that of Stratus OCT at a comparable specificity.
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