April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
African Descent and Glaucoma Evaluation Study (ADAGES): Ancestry Differences in Optic Disc Hemorrhages and Beta-Zone Parapapillary Atrophy
Jeffrey M. Liebmann; Carlos G. De Moraes; Robert Ritch; Christopher Bowd; Pamela A. Sample; Christopher A. Girkin; Felipe A. Medeiros; Robert N. Weinreb; Linda M. Zangwill; ADAGES
Author Affiliations & Notes
  • Jeffrey M. Liebmann
    Ophthalmology, NYU School of Medicine, New York, New York
  • Carlos G. De Moraes
    Ophthalmology, New York Univ School of Medicine, New York, New York
  • Robert Ritch
    Ophthalmology, New York Eye & Ear Infirmary, New York, New York
  • Christopher Bowd
    Ophthalmology, UCSD Hamilton Glaucoma Center, San Diego, California
  • Pamela A. Sample
    Ophthalmology,
    Univ of California-San Diego, La Jolla, California
  • Christopher A. Girkin
    Ophthalmology, Univ of Alabama at Birmingham, Birmingham, Alabama
  • Felipe A. Medeiros
    Ophthalmology,
    Univ of California-San Diego, La Jolla, California
  • Robert N. Weinreb
    Hamilton Glaucoma Center,
    Univ of California-San Diego, La Jolla, California
  • Linda M. Zangwill
    Ophthalmology,
    Univ of California-San Diego, La Jolla, California
  • ADAGES
    Ophthalmology, NYU School of Medicine, New York, New York
  • Footnotes
    Commercial Relationships  Jeffrey M. Liebmann, Alcon Laboratories Inc (C), Allergan Inc (C), Carl Zeiss Meditec Inc (C), Dyopsis Inc (F, C), Pfizer Inc (C), Topcon Medical Systems Inc (F, C); Carlos G. De Moraes, None; Robert Ritch, Dyopsis Inc (F, C), Pfizer Inc (C), Topcon Medical Systems Inc (F, C); Christopher Bowd, Pfizer Inc (F); Pamela A. Sample, Carl Zeiss Meditec Inc (F), Haag-Streit (F); Christopher A. Girkin, Alcon Laboratories Inc (F), Allergan Inc (F), Carl Zeiss Meditec Inc (R), Heidelberg Engineering GmbH (R), Merck Inc (R), Optove Inc (R), Pfizer Inc (F), Topcon Medical Systems Inc (R); Felipe A. Medeiros, Alcon Laboratories Inc (F, C, R), Allergan Inc (C, R), Carl Zeiss Meditec Inc (F, R), Pfizer Inc (F, C, R), Reichert Inc (R); Robert N. Weinreb, Alcon Laboratories Inc (C), Allergan Inc (C), Carl Zeiss Meditec Inc (F, C), Glaxo (C), Heidelberg Engineering GmbH (F), Novartis (F), Optovue Inc (F, C), Pfizer Inc (C), Topcon Medical Systems (F, C); Linda M. Zangwill, Carl Zeiss Meditec Inc (F), Heidelberg Engineering (R), Heidelberg Engineering GmbH (F), Optovue Inc (F), Topcon Medical Systems Inc (F)
  • Footnotes
    Support  NEI grants U10EY14267, EY08208, EY11008, EY019869, EY13959; Eyesight Found. of Alabama; Alcon Labs Inc.; Allergan Inc.; Pfizer Inc.; Merck Inc.; Santen Inc.; Corrine Graber Research Fund of NYGRI
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 204. doi:
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      Jeffrey M. Liebmann, Carlos G. De Moraes, Robert Ritch, Christopher Bowd, Pamela A. Sample, Christopher A. Girkin, Felipe A. Medeiros, Robert N. Weinreb, Linda M. Zangwill, ADAGES; African Descent and Glaucoma Evaluation Study (ADAGES): Ancestry Differences in Optic Disc Hemorrhages and Beta-Zone Parapapillary Atrophy. Invest. Ophthalmol. Vis. Sci. 2011;52(14):204.

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Abstract

Purpose: : We investigated differences in incidence and prevalence of DH and βPPA, respectively, between eyes of people of African (AD) and European descent (ED) which could account for differences in the susceptibility to glaucoma.

Methods: : Stereoscopic disc photographs of subjects with and without glaucomatous optic neuropathy (GON) followed longitudinally during the initial 24 months of ADAGES underwent masked review searching for DH and βPPA. 351 AD eyes and 467 ED eyes with GON and 584 AD and 573 ED eyes without GON were included. The number of eyes with at least one detected DH any time during follow-up and eyes with βPPA were compared between the AD and ED groups. Secondary analyses included horizontal (HCDR) and vertical cup-to-disc ratio (VCDR), age, and refractive error (spherical equivalent, SE) between groups.

Results: : A total of 21 eyes with DH and 139 eyes with βPPA were identified. ED eyes were generally older than AD eyes (p<0.001). ED eyes without GON were more myopic than AD eyes without GON (p=0.017). βPPA occurred more commonly in ED than in AD eyes, regardless of whether they had GON (p<0.001) or not (p<0.001). For GON eyes, ED eyes tended to have more DH (3.2% vs. 1.4%, p=0.11) and a greater prevalence of βPPA than AD eyes (14.7% vs. 6.2%, p<0.01). Ancestry was not associated with DH after adjusting for differences in age, SE, HCDR, and VCDR (p=0.26). However, AD was protective for βPPA even after adjusting for these covariates (OR=0.43, p=0.002). This was also true for non-GON eyes (OR= 0.22, p<0.01). Only one eye without GON (ED) had a detected DH.

Conclusions: : Individuals of AD had lower incidence and prevalence of DH and βPPA, respectively. African ancestry was independently protective for βPPA but not DH. Similar to what has been described in age-related macular degeneration, atrophic abnormalities of the posterior retinal layers around the optic disc are less frequent in AD than ED eyes.

Clinical Trial: : http://www.clinicaltrials.gov NCT00221923

Keywords: optic disc • detection • anatomy 
© 2011, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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